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Exploiting the promiscuity of imatinib
The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 Å crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificit...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689438/ https://www.ncbi.nlm.nih.gov/pubmed/19435483 http://dx.doi.org/10.1186/jbiol134 |
| _version_ | 1782167790837301248 |
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| author | Lee, Shun J Wang, Jean YJ |
| author_facet | Lee, Shun J Wang, Jean YJ |
| author_sort | Lee, Shun J |
| collection | PubMed |
| description | The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 Å crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor. |
| format | Text |
| id | pubmed-2689438 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-26894382009-10-15 Exploiting the promiscuity of imatinib Lee, Shun J Wang, Jean YJ J Biol Minireview The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 Å crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor. BioMed Central 2009 2009-04-15 /pmc/articles/PMC2689438/ /pubmed/19435483 http://dx.doi.org/10.1186/jbiol134 Text en Copyright © 2009 BioMed Central Ltd |
| spellingShingle | Minireview Lee, Shun J Wang, Jean YJ Exploiting the promiscuity of imatinib |
| title | Exploiting the promiscuity of imatinib |
| title_full | Exploiting the promiscuity of imatinib |
| title_fullStr | Exploiting the promiscuity of imatinib |
| title_full_unstemmed | Exploiting the promiscuity of imatinib |
| title_short | Exploiting the promiscuity of imatinib |
| title_sort | exploiting the promiscuity of imatinib |
| topic | Minireview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689438/ https://www.ncbi.nlm.nih.gov/pubmed/19435483 http://dx.doi.org/10.1186/jbiol134 |
| work_keys_str_mv | AT leeshunj exploitingthepromiscuityofimatinib AT wangjeanyj exploitingthepromiscuityofimatinib |