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Neuroimmune perspectives in sepsis
Physiologic anti-inflammatory mechanisms are selected by evolution to control the immune system and to prevent infectious and inflammatory disorders. Central-acting α(2)-agonists attenuate systemic inflammation and improve survival in experimental sepsis. This anti-inflammatory and therapeutic mecha...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689482/ https://www.ncbi.nlm.nih.gov/pubmed/19439052 http://dx.doi.org/10.1186/cc7758 |
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author | Ulloa, Luis Deitch, Edwin A |
author_facet | Ulloa, Luis Deitch, Edwin A |
author_sort | Ulloa, Luis |
collection | PubMed |
description | Physiologic anti-inflammatory mechanisms are selected by evolution to control the immune system and to prevent infectious and inflammatory disorders. Central-acting α(2)-agonists attenuate systemic inflammation and improve survival in experimental sepsis. This anti-inflammatory and therapeutic mechanism of central sympatholytics appears to be mediated by an unexpected vagomimetic potential of the α(2)-agonists to activate the vagus nerve. Recent studies, however, rule out a cholinergic anti-inflammatory mechanism based on a direct cholinergic interaction between the vagus nerve and the immune system. Since the nervous system is the principal regulator of the immune system, physiologic studies understanding the neuroimmune connections can provide major advantages to design novel therapeutic strategies for sepsis. |
format | Text |
id | pubmed-2689482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26894822010-04-23 Neuroimmune perspectives in sepsis Ulloa, Luis Deitch, Edwin A Crit Care Commentary Physiologic anti-inflammatory mechanisms are selected by evolution to control the immune system and to prevent infectious and inflammatory disorders. Central-acting α(2)-agonists attenuate systemic inflammation and improve survival in experimental sepsis. This anti-inflammatory and therapeutic mechanism of central sympatholytics appears to be mediated by an unexpected vagomimetic potential of the α(2)-agonists to activate the vagus nerve. Recent studies, however, rule out a cholinergic anti-inflammatory mechanism based on a direct cholinergic interaction between the vagus nerve and the immune system. Since the nervous system is the principal regulator of the immune system, physiologic studies understanding the neuroimmune connections can provide major advantages to design novel therapeutic strategies for sepsis. BioMed Central 2009 2009-04-23 /pmc/articles/PMC2689482/ /pubmed/19439052 http://dx.doi.org/10.1186/cc7758 Text en Copyright © 2009 BioMed Central Ltd |
spellingShingle | Commentary Ulloa, Luis Deitch, Edwin A Neuroimmune perspectives in sepsis |
title | Neuroimmune perspectives in sepsis |
title_full | Neuroimmune perspectives in sepsis |
title_fullStr | Neuroimmune perspectives in sepsis |
title_full_unstemmed | Neuroimmune perspectives in sepsis |
title_short | Neuroimmune perspectives in sepsis |
title_sort | neuroimmune perspectives in sepsis |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689482/ https://www.ncbi.nlm.nih.gov/pubmed/19439052 http://dx.doi.org/10.1186/cc7758 |
work_keys_str_mv | AT ulloaluis neuroimmuneperspectivesinsepsis AT deitchedwina neuroimmuneperspectivesinsepsis |