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High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States

Replication and pathogenesis of the human immunodeficiency virus (HIV) is tightly linked to the structure of its RNA genome, but genome structure in infectious virions is poorly understood. We invent high-throughput SHAPE (selective 2′-hydroxyl acylation analyzed by primer extension) technology, whi...

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Detalles Bibliográficos
Autores principales:	Wilkinson, Kevin A, Gorelick, Robert J, Vasa, Suzy M, Guex, Nicolas, Rein, Alan, Mathews, David H, Giddings, Morgan C, Weeks, Kevin M
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689691/ https://www.ncbi.nlm.nih.gov/pubmed/18447581 http://dx.doi.org/10.1371/journal.pbio.0060096

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