Polycomb Group Genes: Keeping Stem Cell Activity in Balance

Overexpression of Polycomb group genes is often associated with cancer development, whereas complete deletion results in loss of stem cell activity. New studies show that partial loss of function of Polycomb group genes enhances the activity of blood stem/progenitor cells.

Detalles Bibliográficos
Autores principales: Sauvageau, Martin, Sauvageau, Guy
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689701/
https://www.ncbi.nlm.nih.gov/pubmed/18447587
http://dx.doi.org/10.1371/journal.pbio.0060113
Descripción
Sumario:Overexpression of Polycomb group genes is often associated with cancer development, whereas complete deletion results in loss of stem cell activity. New studies show that partial loss of function of Polycomb group genes enhances the activity of blood stem/progenitor cells.

Ejemplares similares