Polycomb Group Genes: Keeping Stem Cell Activity in Balance

Overexpression of Polycomb group genes is often associated with cancer development, whereas complete deletion results in loss of stem cell activity. New studies show that partial loss of function of Polycomb group genes enhances the activity of blood stem/progenitor cells.

Detalles Bibliográficos
Autores principales: Sauvageau, Martin, Sauvageau, Guy
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689701/
https://www.ncbi.nlm.nih.gov/pubmed/18447587
http://dx.doi.org/10.1371/journal.pbio.0060113
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author Sauvageau, Martin
Sauvageau, Guy
author_facet Sauvageau, Martin
Sauvageau, Guy
author_sort Sauvageau, Martin
collection PubMed
description Overexpression of Polycomb group genes is often associated with cancer development, whereas complete deletion results in loss of stem cell activity. New studies show that partial loss of function of Polycomb group genes enhances the activity of blood stem/progenitor cells.
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spelling pubmed-26897012009-06-02 Polycomb Group Genes: Keeping Stem Cell Activity in Balance Sauvageau, Martin Sauvageau, Guy PLoS Biol Primer Overexpression of Polycomb group genes is often associated with cancer development, whereas complete deletion results in loss of stem cell activity. New studies show that partial loss of function of Polycomb group genes enhances the activity of blood stem/progenitor cells. Public Library of Science 2008-04 2008-04-29 /pmc/articles/PMC2689701/ /pubmed/18447587 http://dx.doi.org/10.1371/journal.pbio.0060113 Text en © 2008 Sauvageau and Sauvageau. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Primer
Sauvageau, Martin
Sauvageau, Guy
Polycomb Group Genes: Keeping Stem Cell Activity in Balance
title Polycomb Group Genes: Keeping Stem Cell Activity in Balance
title_full Polycomb Group Genes: Keeping Stem Cell Activity in Balance
title_fullStr Polycomb Group Genes: Keeping Stem Cell Activity in Balance
title_full_unstemmed Polycomb Group Genes: Keeping Stem Cell Activity in Balance
title_short Polycomb Group Genes: Keeping Stem Cell Activity in Balance
title_sort polycomb group genes: keeping stem cell activity in balance
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689701/
https://www.ncbi.nlm.nih.gov/pubmed/18447587
http://dx.doi.org/10.1371/journal.pbio.0060113
work_keys_str_mv AT sauvageaumartin polycombgroupgeneskeepingstemcellactivityinbalance
AT sauvageauguy polycombgroupgeneskeepingstemcellactivityinbalance

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