A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

The nonsense-mediated decay (NMD) pathway subjects mRNAs with premature termination codons (PTCs) to rapid decay. The conserved Upf1–3 complex interacts with the eukaryotic translation release factors, eRF3 and eRF1, and triggers NMD when translation termination takes place at a PTC. Contrasting mod...

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Detalles Bibliográficos
Autores principales: Singh, Guramrit, Rebbapragada, Indrani, Lykke-Andersen, Jens
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689706/
https://www.ncbi.nlm.nih.gov/pubmed/18447585
http://dx.doi.org/10.1371/journal.pbio.0060111

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