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Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis

BACKGROUND: Recombinant adenovirus-vectored (Ad) tuberculosis (TB) vaccine platform has demonstrated great potential to be used either as a stand-alone or a boost vaccine in murine models. However, Ad TB vaccine remains to be evaluated in a more relevant and sensitive guinea pig model of pulmonary T...

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Detalles Bibliográficos
Autores principales:	Xing, Zhou, McFarland, Christine T., Sallenave, Jean-Michel, Izzo, Angelo, Wang, Jun, McMurray, David N.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689939/ https://www.ncbi.nlm.nih.gov/pubmed/19516906 http://dx.doi.org/10.1371/journal.pone.0005856

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