Zinc Coordination Is Required for and Regulates Transcription Activation by Epstein-Barr Nuclear Antigen 1

Epstein-Barr Nuclear Antigen 1 (EBNA1) is essential for Epstein-Barr virus to immortalize naïve B-cells. Upon binding a cluster of 20 cognate binding-sites termed the family of repeats, EBNA1 transactivates promoters for EBV genes that are required for immortalization. A small domain, termed UR1, th...

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Detalles Bibliográficos
Autores principales: Aras, Siddhesh, Singh, Gyanendra, Johnston, Kenneth, Foster, Timothy, Aiyar, Ashok
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690687/
https://www.ncbi.nlm.nih.gov/pubmed/19521517
http://dx.doi.org/10.1371/journal.ppat.1000469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690687/
https://www.ncbi.nlm.nih.gov/pubmed/19521517
http://dx.doi.org/10.1371/journal.ppat.1000469

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