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Aging Is Not Associated with Proteasome Impairment in UPS Reporter Mice

BACKGROUND: Covalent linkage of ubiquitin regulates the function and, ultimately, the degradation of many proteins by the ubiquitin-proteasome system (UPS). Given its essential role in protein regulation, even slight perturbations in UPS activity can substantially impair cellular function. METHODOLO...

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Detalles Bibliográficos
Autores principales:	Cook, Casey, Gass, Jennifer, Dunmore, Judith, Tong, Jimei, Taylor, Julie, Eriksen, Jason, McGowan, Eileen, Lewis, Jada, Johnston, Jennifer, Petrucelli, Leonard
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690827/ https://www.ncbi.nlm.nih.gov/pubmed/19517018 http://dx.doi.org/10.1371/journal.pone.0005888

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