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Identification of I(Kr) Kinetics and Drug Binding in Native Myocytes

Determining the effect of a compound on I(Kr) is a standard screen for drug safety. Often the effect is described using a single IC(50) value, which is unable to capture complex effects of a drug. Using verapamil as an example, we present a method for using recordings from native myocytes at several...

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Detalles Bibliográficos
Autores principales:	Zhou, Qinlian, Zygmunt, Andrew C., Cordeiro, Jonathan M., Siso-Nadal, Fernando, Miller, Robert E., Buzzard, Gregery T., Fox, Jeffrey J.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer US 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690829/ https://www.ncbi.nlm.nih.gov/pubmed/19353268 http://dx.doi.org/10.1007/s10439-009-9690-5

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