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CPEB3 is Associated with Human Episodic Memory
Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans, the ribozyme sequence...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691156/ https://www.ncbi.nlm.nih.gov/pubmed/19503753 http://dx.doi.org/10.3389/neuro.08.004.2009 |
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author | Vogler, Christian Spalek, Klara Aerni, Amanda Demougin, Philippe Müller, Ariane Huynh, Kim-Dung Papassotiropoulos, Andreas de Quervain, Dominique J.-F. |
author_facet | Vogler, Christian Spalek, Klara Aerni, Amanda Demougin, Philippe Müller, Ariane Huynh, Kim-Dung Papassotiropoulos, Andreas de Quervain, Dominique J.-F. |
author_sort | Vogler, Christian |
collection | PubMed |
description | Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans, the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism that influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data suggest a role for human CPEB3 in human episodic memory. |
format | Text |
id | pubmed-2691156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-26911562009-06-05 CPEB3 is Associated with Human Episodic Memory Vogler, Christian Spalek, Klara Aerni, Amanda Demougin, Philippe Müller, Ariane Huynh, Kim-Dung Papassotiropoulos, Andreas de Quervain, Dominique J.-F. Front Behav Neurosci Neuroscience Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans, the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism that influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data suggest a role for human CPEB3 in human episodic memory. Frontiers Research Foundation 2009-05-04 /pmc/articles/PMC2691156/ /pubmed/19503753 http://dx.doi.org/10.3389/neuro.08.004.2009 Text en Copyright © 2009 Vogler, Spalek, Aerni, Demougin, Müller, Huynh, Papassotiropoulos and de Quervain. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Vogler, Christian Spalek, Klara Aerni, Amanda Demougin, Philippe Müller, Ariane Huynh, Kim-Dung Papassotiropoulos, Andreas de Quervain, Dominique J.-F. CPEB3 is Associated with Human Episodic Memory |
title | CPEB3 is Associated with Human Episodic Memory |
title_full | CPEB3 is Associated with Human Episodic Memory |
title_fullStr | CPEB3 is Associated with Human Episodic Memory |
title_full_unstemmed | CPEB3 is Associated with Human Episodic Memory |
title_short | CPEB3 is Associated with Human Episodic Memory |
title_sort | cpeb3 is associated with human episodic memory |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691156/ https://www.ncbi.nlm.nih.gov/pubmed/19503753 http://dx.doi.org/10.3389/neuro.08.004.2009 |
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