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SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways
Changes in cellular ion levels can modulate distinct signaling networks aimed at correcting major disruptions in ion balances that might otherwise threaten cell growth and development. Salt-inducible kinase 1 (SIK1) and salt overly sensitive 2 (SOS2) are key protein kinases within such networks in m...
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691526/ https://www.ncbi.nlm.nih.gov/pubmed/19247687 http://dx.doi.org/10.1007/s00424-009-0646-2 |
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author | Bertorello, Alejandro Mario Zhu, Jian-Kang |
author_facet | Bertorello, Alejandro Mario Zhu, Jian-Kang |
author_sort | Bertorello, Alejandro Mario |
collection | PubMed |
description | Changes in cellular ion levels can modulate distinct signaling networks aimed at correcting major disruptions in ion balances that might otherwise threaten cell growth and development. Salt-inducible kinase 1 (SIK1) and salt overly sensitive 2 (SOS2) are key protein kinases within such networks in mammalian and plant cells, respectively. In animals, SIK1 expression and activity are regulated in response to the salt content of the diet, and in plants SOS2 activity is controlled by the salinity of the soil. The specific ionic stress (elevated intracellular sodium) is followed by changes in intracellular calcium; the calcium signals are sensed by calcium-binding proteins and lead to activation of SIK1 or SOS2. These kinases target major plasma membrane transporters such as the Na(+),K(+)-ATPase in mammalian cells, and Na(+)/H(+) exchangers in the plasma membrane and membranes of intracellular vacuoles of plant cells. Activation of these networks prevents abnormal increases in intracellular sodium concentration. |
format | Text |
id | pubmed-2691526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-26915262009-06-05 SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways Bertorello, Alejandro Mario Zhu, Jian-Kang Pflugers Arch Signaling and Cell Physiology Changes in cellular ion levels can modulate distinct signaling networks aimed at correcting major disruptions in ion balances that might otherwise threaten cell growth and development. Salt-inducible kinase 1 (SIK1) and salt overly sensitive 2 (SOS2) are key protein kinases within such networks in mammalian and plant cells, respectively. In animals, SIK1 expression and activity are regulated in response to the salt content of the diet, and in plants SOS2 activity is controlled by the salinity of the soil. The specific ionic stress (elevated intracellular sodium) is followed by changes in intracellular calcium; the calcium signals are sensed by calcium-binding proteins and lead to activation of SIK1 or SOS2. These kinases target major plasma membrane transporters such as the Na(+),K(+)-ATPase in mammalian cells, and Na(+)/H(+) exchangers in the plasma membrane and membranes of intracellular vacuoles of plant cells. Activation of these networks prevents abnormal increases in intracellular sodium concentration. Springer-Verlag 2009-02-27 2009-07 /pmc/articles/PMC2691526/ /pubmed/19247687 http://dx.doi.org/10.1007/s00424-009-0646-2 Text en © The Author(s) 2009 |
spellingShingle | Signaling and Cell Physiology Bertorello, Alejandro Mario Zhu, Jian-Kang SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways |
title | SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways |
title_full | SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways |
title_fullStr | SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways |
title_full_unstemmed | SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways |
title_short | SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways |
title_sort | sik1/sos2 networks: decoding sodium signals via calcium-responsive protein kinase pathways |
topic | Signaling and Cell Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691526/ https://www.ncbi.nlm.nih.gov/pubmed/19247687 http://dx.doi.org/10.1007/s00424-009-0646-2 |
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