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Selective Processing and Metabolism of Disease-Causing Mutant Prion Proteins
Prion diseases are fatal neurodegenerative disorders caused by aberrant metabolism of the cellular prion protein (PrP(C)). In genetic forms of these diseases, mutations in the globular C-terminal domain are hypothesized to favor the spontaneous generation of misfolded PrP conformers (including the t...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691595/ https://www.ncbi.nlm.nih.gov/pubmed/19543376 http://dx.doi.org/10.1371/journal.ppat.1000479 |