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siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells

BACKGROUND: Doxorubicin is an effective breast cancer drug but is hampered by a severe, dose-dependent toxicity. Concomitant administration of doxorubicin and another cancer drug may be able to sensitize tumor cells to the cytotoxicity of doxorubicin and lowers the therapeutic dosage. In this study,...

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Detalles Bibliográficos
Autores principales: Dong, Xuejun, Liu, Anding, Zer, Cindy, Feng, Jianguo, Zhen, Zhuan, Yang, Mingfeng, Zhong, Li
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691745/
https://www.ncbi.nlm.nih.gov/pubmed/19416503
http://dx.doi.org/10.1186/1471-2407-9-133