Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E–eIF4G interactions

Translation initiation in eukaryotes is mediated by assembly of the eIF4F complex over the m(7)GTP cap structure at the 5′-end of mRNAs. This requires an interaction between eIF4E and eIF4G, two eIF4F subunits. The Leishmania orthologs of eIF4E are structurally diverged from their higher eukaryote c...

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Detalles Bibliográficos
Autores principales: Yoffe, Yael, Léger, Mélissa, Zinoviev, Alexandra, Zuberek, Joanna, Darzynkiewicz, Edward, Wagner, Gerhard, Shapira, Michal
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691829/
https://www.ncbi.nlm.nih.gov/pubmed/19321500
http://dx.doi.org/10.1093/nar/gkp190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691829/
https://www.ncbi.nlm.nih.gov/pubmed/19321500
http://dx.doi.org/10.1093/nar/gkp190

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