The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. METHODOLOGY AND PRINCIPAL FINDINGS: Patients were subdivided as having limited cutaneous SSc (lcSSc, n = 12)...

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Detalles Bibliográficos
Autores principales: Radstake, Timothy R. D. J., van Bon, Lenny, Broen, Jasper, Hussiani, Anila, Hesselstrand, Roger, Wuttge, Dirk M., Deng, Yanhui, Simms, Robbert, Lubberts, Erik, Lafyatis, Robert
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691991/
https://www.ncbi.nlm.nih.gov/pubmed/19536281
http://dx.doi.org/10.1371/journal.pone.0005903

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