5′-Fluoro-5′-deoxyaristeromycin

5′-Fluoro-5′-deoxyaristeromycin (2) has been prepared via a Mitsunobu coupling of (1S,2S,3R,4S)-2,3-(cyclopentylidenedioxy)-4-fluoromethylcyclopentan-1-ol with N(6)-bis-boc protected adenine. This procedure is adaptable to preparing a number of 5′-fluoro-5′-deoxycarbocyclic nucleoside analogs with d...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Weikuan, Yin, Xueqiang, Schneller, Stewart W.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692407/
https://www.ncbi.nlm.nih.gov/pubmed/18023578
http://dx.doi.org/10.1016/j.bmcl.2007.10.095
_version_ 1782167934575050752
author Li, Weikuan
Yin, Xueqiang
Schneller, Stewart W.
author_facet Li, Weikuan
Yin, Xueqiang
Schneller, Stewart W.
author_sort Li, Weikuan
collection PubMed
description 5′-Fluoro-5′-deoxyaristeromycin (2) has been prepared via a Mitsunobu coupling of (1S,2S,3R,4S)-2,3-(cyclopentylidenedioxy)-4-fluoromethylcyclopentan-1-ol with N(6)-bis-boc protected adenine. This procedure is adaptable to preparing a number of 5′-fluoro-5′-deoxycarbocyclic nucleoside analogs with diversity in the heterocyclic base. Antiviral analysis found promising activity for 2 toward measles but no other viruses. No cytotoxicity was observed for 2.
format Text
id pubmed-2692407
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-26924072009-06-08 5′-Fluoro-5′-deoxyaristeromycin Li, Weikuan Yin, Xueqiang Schneller, Stewart W. Bioorg Med Chem Lett Article 5′-Fluoro-5′-deoxyaristeromycin (2) has been prepared via a Mitsunobu coupling of (1S,2S,3R,4S)-2,3-(cyclopentylidenedioxy)-4-fluoromethylcyclopentan-1-ol with N(6)-bis-boc protected adenine. This procedure is adaptable to preparing a number of 5′-fluoro-5′-deoxycarbocyclic nucleoside analogs with diversity in the heterocyclic base. Antiviral analysis found promising activity for 2 toward measles but no other viruses. No cytotoxicity was observed for 2. Elsevier Ltd. 2008-01-01 2007-10-30 /pmc/articles/PMC2692407/ /pubmed/18023578 http://dx.doi.org/10.1016/j.bmcl.2007.10.095 Text en Copyright © 2007 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Weikuan
Yin, Xueqiang
Schneller, Stewart W.
5′-Fluoro-5′-deoxyaristeromycin
title 5′-Fluoro-5′-deoxyaristeromycin
title_full 5′-Fluoro-5′-deoxyaristeromycin
title_fullStr 5′-Fluoro-5′-deoxyaristeromycin
title_full_unstemmed 5′-Fluoro-5′-deoxyaristeromycin
title_short 5′-Fluoro-5′-deoxyaristeromycin
title_sort 5′-fluoro-5′-deoxyaristeromycin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692407/
https://www.ncbi.nlm.nih.gov/pubmed/18023578
http://dx.doi.org/10.1016/j.bmcl.2007.10.095
work_keys_str_mv AT liweikuan 5fluoro5deoxyaristeromycin
AT yinxueqiang 5fluoro5deoxyaristeromycin
AT schnellerstewartw 5fluoro5deoxyaristeromycin

Ejemplares similares