Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent

BACKGROUND: Deletion or mutation(s) of the survival motor neuron 1 (SMN1) gene causes spinal muscular atrophy (SMA). The SMN protein is known to play a role in RNA metabolism, neurite outgrowth, and cell survival. Yet, it remains unclear how SMN deficiency causes selective motor neuron death and mus...

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Detalles Bibliográficos
Autores principales: Wu, Chia-Yen, Gómez-Curet, Ilsa, Funanage, Vicky L, Scavina, Mena, Wang, Wenlan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692972/
https://www.ncbi.nlm.nih.gov/pubmed/19445707
http://dx.doi.org/10.1186/1471-2121-10-40

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