Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb

Using 2-photon-guided focal stimulation, we demonstrate spike timing-dependent plasticity of proximal excitatory inputs to olfactory bulb granule cells that originate, in part, from cortical feedback projections. The protocol that potentiated proximal inputs depressed distal, dendrodendritic inputs...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Strowbridge, Ben W.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693249/
https://www.ncbi.nlm.nih.gov/pubmed/19412165
http://dx.doi.org/10.1038/nn.2319
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author Gao, Yuan
Strowbridge, Ben W.
author_facet Gao, Yuan
Strowbridge, Ben W.
author_sort Gao, Yuan
collection PubMed
description Using 2-photon-guided focal stimulation, we demonstrate spike timing-dependent plasticity of proximal excitatory inputs to olfactory bulb granule cells that originate, in part, from cortical feedback projections. The protocol that potentiated proximal inputs depressed distal, dendrodendritic inputs to granule cells. Granule cell EPSPs, and mitral cell inhibition, also were potentiated by theta-burst stimulation. Plasticity of cortical feedback inputs to interneurons provides a novel mechanism to encode information by modulating bulbar inhibition.
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spelling pubmed-26932492009-12-01 Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb Gao, Yuan Strowbridge, Ben W. Nat Neurosci Article Using 2-photon-guided focal stimulation, we demonstrate spike timing-dependent plasticity of proximal excitatory inputs to olfactory bulb granule cells that originate, in part, from cortical feedback projections. The protocol that potentiated proximal inputs depressed distal, dendrodendritic inputs to granule cells. Granule cell EPSPs, and mitral cell inhibition, also were potentiated by theta-burst stimulation. Plasticity of cortical feedback inputs to interneurons provides a novel mechanism to encode information by modulating bulbar inhibition. 2009-05-03 2009-06 /pmc/articles/PMC2693249/ /pubmed/19412165 http://dx.doi.org/10.1038/nn.2319 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gao, Yuan
Strowbridge, Ben W.
Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb
title Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb
title_full Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb
title_fullStr Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb
title_full_unstemmed Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb
title_short Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb
title_sort long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693249/
https://www.ncbi.nlm.nih.gov/pubmed/19412165
http://dx.doi.org/10.1038/nn.2319
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AT strowbridgebenw longtermplasticityofexcitatoryinputstogranulecellsintheratolfactorybulb

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