RAG1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

Coordinated recombination of homologous antigen receptor loci is thought to be important for allelic exclusion. Here, we show that homologous Ig alleles pair in a stage-specific manner that mirrors the recombination patterns of these loci. The frequency of homologous Ig pairing was substantially red...

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Detalles Bibliográficos
Autores principales: Hewitt, Susannah L., Yin, Bu, Ji, Yanhong, Chaumeil, Julie, Marszalek, Katarzyna, Tenthorey, Jeannette, Salvagiotto, Giorgia, Steinel, Natalie, Ramsey, Laura B., Ghysdael, Jacques, Farrar, Michael A., Sleckman, Barry P., Schatz, David G., Busslinger, Meinrad, Bassing, Craig H., Skok, Jane A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693356/
https://www.ncbi.nlm.nih.gov/pubmed/19448632
http://dx.doi.org/10.1038/ni.1735

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