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The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity

BACKGROUND: Plasminogen activator inhibitor type-2 (PAI-2, SERPINB2) is an irreversible, specific inhibitor of the urokinase plasminogen activator (uPA). Since overexpression of uPA at the surface of cancer cells is linked to malignancy, targeting of uPA by exogenous recombinant PAI-2 has been propo...

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Detalles Bibliográficos
Autores principales:	Cochran, Blake J, Gunawardhana, Lakshitha P, Vine, Kara L, Lee, Jodi A, Lobov, Sergei, Ranson, Marie
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693429/ https://www.ncbi.nlm.nih.gov/pubmed/19442270 http://dx.doi.org/10.1186/1472-6750-9-43

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