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Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

Ataxia oculomotor apraxia-1 (AOA1) is an autosomal recessive neurodegenerative disease that results from mutations of aprataxin (APTX). APTX associates with the DNA single- and double-strand break repair machinery and is able to remove AMP from 5′-termini at DNA strand breaks in vitro. However, atte...

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Detalles Bibliográficos
Autores principales:	El-Khamisy, Sherif F., Katyal, Sachin, Patel, Poorvi, Ju, Limei, McKinnon, Peter J., Caldecott, Keith W.
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693503/ https://www.ncbi.nlm.nih.gov/pubmed/19303373 http://dx.doi.org/10.1016/j.dnarep.2009.02.002

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