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Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome

The plasma ghrelin has been reported to be elevated in Prader-Willi syndrome (PWS) and modulated by insulin. It was hypothesized that insulin might have a more pronounced effect on reducing plasma ghrelin in PWS patients, which would influence appetite. This study investigated the degree of ghrelin...

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Autores principales: Paik, Kyung-Hoon, Lee, Moon-Kyu, Jin, Dong-Kyu, Kang, Hahn Wook, Lee, Kyung Han, Kim, An Hee, Kim, Cheol, Lee, Ji Eun, Oh, Yoo Joung, Kim, Seonwoo, Han, Sun Joo, Kwon, Eun Kyung, Choe, Yon Ho
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693578/
https://www.ncbi.nlm.nih.gov/pubmed/17449920
http://dx.doi.org/10.3346/jkms.2007.22.2.177
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author Paik, Kyung-Hoon
Lee, Moon-Kyu
Jin, Dong-Kyu
Kang, Hahn Wook
Lee, Kyung Han
Kim, An Hee
Kim, Cheol
Lee, Ji Eun
Oh, Yoo Joung
Kim, Seonwoo
Han, Sun Joo
Kwon, Eun Kyung
Choe, Yon Ho
author_facet Paik, Kyung-Hoon
Lee, Moon-Kyu
Jin, Dong-Kyu
Kang, Hahn Wook
Lee, Kyung Han
Kim, An Hee
Kim, Cheol
Lee, Ji Eun
Oh, Yoo Joung
Kim, Seonwoo
Han, Sun Joo
Kwon, Eun Kyung
Choe, Yon Ho
author_sort Paik, Kyung-Hoon
collection PubMed
description The plasma ghrelin has been reported to be elevated in Prader-Willi syndrome (PWS) and modulated by insulin. It was hypothesized that insulin might have a more pronounced effect on reducing plasma ghrelin in PWS patients, which would influence appetite. This study investigated the degree of ghrelin suppression using an euglycemic hyperinsulinemic clamp in children with PWS (n=6) and normal children (n=6). After a 90-min infusion of insulin, the plasma ghrelin level decreased from a basal value of 0.86±0.15 to 0.58±0.12 ng/mL in the controls, and from 2.38±0.76 to 1.12±0.29 ng/mL in children with PWS (p=0.011). The area under the curve below the baseline level over the 90 min insulin infusion was larger in children with PWS than in controls (-92.82±44.4 vs. -10.41±2.87 ng/mL/90 min) (p=0.011). The insulin sensitivity measured as the glucose infusion rate at steady state was similar in the two groups (p=0.088). The decrease in the ghrelin levels in response to insulin was more pronounced in the children with PWS than in the controls. However, the level of ghrelin was always higher in the children with PWS during the clamp study. This suggests that even though insulin sensitivity to ghrelin is well maintained, an increase in the baseline ghrelin levels is characteristic of PWS.
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spelling pubmed-26935782009-06-11 Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome Paik, Kyung-Hoon Lee, Moon-Kyu Jin, Dong-Kyu Kang, Hahn Wook Lee, Kyung Han Kim, An Hee Kim, Cheol Lee, Ji Eun Oh, Yoo Joung Kim, Seonwoo Han, Sun Joo Kwon, Eun Kyung Choe, Yon Ho J Korean Med Sci Original Article The plasma ghrelin has been reported to be elevated in Prader-Willi syndrome (PWS) and modulated by insulin. It was hypothesized that insulin might have a more pronounced effect on reducing plasma ghrelin in PWS patients, which would influence appetite. This study investigated the degree of ghrelin suppression using an euglycemic hyperinsulinemic clamp in children with PWS (n=6) and normal children (n=6). After a 90-min infusion of insulin, the plasma ghrelin level decreased from a basal value of 0.86±0.15 to 0.58±0.12 ng/mL in the controls, and from 2.38±0.76 to 1.12±0.29 ng/mL in children with PWS (p=0.011). The area under the curve below the baseline level over the 90 min insulin infusion was larger in children with PWS than in controls (-92.82±44.4 vs. -10.41±2.87 ng/mL/90 min) (p=0.011). The insulin sensitivity measured as the glucose infusion rate at steady state was similar in the two groups (p=0.088). The decrease in the ghrelin levels in response to insulin was more pronounced in the children with PWS than in the controls. However, the level of ghrelin was always higher in the children with PWS during the clamp study. This suggests that even though insulin sensitivity to ghrelin is well maintained, an increase in the baseline ghrelin levels is characteristic of PWS. The Korean Academy of Medical Sciences 2007-04 2007-04-30 /pmc/articles/PMC2693578/ /pubmed/17449920 http://dx.doi.org/10.3346/jkms.2007.22.2.177 Text en Copyright © 2007 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Paik, Kyung-Hoon
Lee, Moon-Kyu
Jin, Dong-Kyu
Kang, Hahn Wook
Lee, Kyung Han
Kim, An Hee
Kim, Cheol
Lee, Ji Eun
Oh, Yoo Joung
Kim, Seonwoo
Han, Sun Joo
Kwon, Eun Kyung
Choe, Yon Ho
Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome
title Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome
title_full Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome
title_fullStr Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome
title_full_unstemmed Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome
title_short Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome
title_sort marked suppression of ghrelin concentration by insulin in prader-willi syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693578/
https://www.ncbi.nlm.nih.gov/pubmed/17449920
http://dx.doi.org/10.3346/jkms.2007.22.2.177
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