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Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients

The aim of the present study was to evaluate plasma total homocysteine (Hcys) and serum fibrinogen concentrations in subclinical hypothyroid (SH) and overt hypothyroid patients before and after L-thyroxine (LT4) replacement and to compare them in euthyroid subjects. Fifteen SH and 20 hypothyroid pre...

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Autores principales: Çakal, Başak, Çakal, Erman, Demirbaş, Berrin, Özkaya, Mesut, Karaahmetoğlu, Selma, Serter, Rüştü, Aral, Yalçin
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693633/
https://www.ncbi.nlm.nih.gov/pubmed/17596649
http://dx.doi.org/10.3346/jkms.2007.22.3.431
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author Çakal, Başak
Çakal, Erman
Demirbaş, Berrin
Özkaya, Mesut
Karaahmetoğlu, Selma
Serter, Rüştü
Aral, Yalçin
author_facet Çakal, Başak
Çakal, Erman
Demirbaş, Berrin
Özkaya, Mesut
Karaahmetoğlu, Selma
Serter, Rüştü
Aral, Yalçin
author_sort Çakal, Başak
collection PubMed
description The aim of the present study was to evaluate plasma total homocysteine (Hcys) and serum fibrinogen concentrations in subclinical hypothyroid (SH) and overt hypothyroid patients before and after L-thyroxine (LT4) replacement and to compare them in euthyroid subjects. Fifteen SH and 20 hypothyroid premenopausal women were recruited in the study. We measured fasting plasma levels of Hcys and serum levels of free thyroxine (fT4), free triiodothyronine (fT3), thyrotropin (TSH), folate, vitamin B12, fibrinogen, renal functions, and lipid profiles in patients with SH and overt hypothyroid patients before and after LT4 treatment. Eleven healthy women were included in the study as a control group. Pretreatment Hcys levels were similar in SH and control subjects, whereas mean fibrinogen level of SH patients was higher than that of control subjects (p<0.05). Baseline Hcys (p<0.01) and fibrinogen (p<0.001) levels of the overt hypothyroid patients were significantly higher than those of the healthy subjects, and the pretreatment Hcys levels decreased with LT4 treatment (p<0.001). In conclusion, our data support that SH is not associated with hyperhomocysteinemia and Hcys does not appear to contribute to the increased risk for atherosclerotic disease in patients with SH.
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spelling pubmed-26936332009-06-11 Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients Çakal, Başak Çakal, Erman Demirbaş, Berrin Özkaya, Mesut Karaahmetoğlu, Selma Serter, Rüştü Aral, Yalçin J Korean Med Sci Original Article The aim of the present study was to evaluate plasma total homocysteine (Hcys) and serum fibrinogen concentrations in subclinical hypothyroid (SH) and overt hypothyroid patients before and after L-thyroxine (LT4) replacement and to compare them in euthyroid subjects. Fifteen SH and 20 hypothyroid premenopausal women were recruited in the study. We measured fasting plasma levels of Hcys and serum levels of free thyroxine (fT4), free triiodothyronine (fT3), thyrotropin (TSH), folate, vitamin B12, fibrinogen, renal functions, and lipid profiles in patients with SH and overt hypothyroid patients before and after LT4 treatment. Eleven healthy women were included in the study as a control group. Pretreatment Hcys levels were similar in SH and control subjects, whereas mean fibrinogen level of SH patients was higher than that of control subjects (p<0.05). Baseline Hcys (p<0.01) and fibrinogen (p<0.001) levels of the overt hypothyroid patients were significantly higher than those of the healthy subjects, and the pretreatment Hcys levels decreased with LT4 treatment (p<0.001). In conclusion, our data support that SH is not associated with hyperhomocysteinemia and Hcys does not appear to contribute to the increased risk for atherosclerotic disease in patients with SH. The Korean Academy of Medical Sciences 2007-06 2007-06-30 /pmc/articles/PMC2693633/ /pubmed/17596649 http://dx.doi.org/10.3346/jkms.2007.22.3.431 Text en Copyright © 2007 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Çakal, Başak
Çakal, Erman
Demirbaş, Berrin
Özkaya, Mesut
Karaahmetoğlu, Selma
Serter, Rüştü
Aral, Yalçin
Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients
title Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients
title_full Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients
title_fullStr Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients
title_full_unstemmed Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients
title_short Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients
title_sort homocysteine and fibrinogen changes with l-thyroxine in subclinical hypothyroid patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693633/
https://www.ncbi.nlm.nih.gov/pubmed/17596649
http://dx.doi.org/10.3346/jkms.2007.22.3.431
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