A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement

We report a case of intolerance to warfarin dosing due to impaired drug metabolism in a patient with CYP2C9*3/*4. A 73-yr-old woman with atrial fibrilation was taking warfarin. She attained a high prothrombin time international normalized ratio (INR) at the standard doses during the induction of ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Soo-Youn, Nam, Myung-Hyun, Kim, June Soo, Kim, Jong-Won
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2007
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693655/
https://www.ncbi.nlm.nih.gov/pubmed/17596671
http://dx.doi.org/10.3346/jkms.2007.22.3.557
_version_ 1782167994761216000
author Lee, Soo-Youn
Nam, Myung-Hyun
Kim, June Soo
Kim, Jong-Won
author_facet Lee, Soo-Youn
Nam, Myung-Hyun
Kim, June Soo
Kim, Jong-Won
author_sort Lee, Soo-Youn
collection PubMed
description We report a case of intolerance to warfarin dosing due to impaired drug metabolism in a patient with CYP2C9*3/*4. A 73-yr-old woman with atrial fibrilation was taking warfarin. She attained a high prothrombin time international normalized ratio (INR) at the standard doses during the induction of anticoagulation and extremely low dose of warfarin (6.5 mg/week) was finally chosen to reach the target INR. Genotyping for CYP2C9 revealed that this patient had a genotype CYP2C9*3/*4. This is the first Korean compound heterozygote for CYP2C9*3 and *4. This case suggests the clinical usefulness of pharmacogenetic testing for individualized dosage adjustments of warfarin.
format Text
id pubmed-2693655
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-26936552009-06-11 A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement Lee, Soo-Youn Nam, Myung-Hyun Kim, June Soo Kim, Jong-Won J Korean Med Sci Case Report We report a case of intolerance to warfarin dosing due to impaired drug metabolism in a patient with CYP2C9*3/*4. A 73-yr-old woman with atrial fibrilation was taking warfarin. She attained a high prothrombin time international normalized ratio (INR) at the standard doses during the induction of anticoagulation and extremely low dose of warfarin (6.5 mg/week) was finally chosen to reach the target INR. Genotyping for CYP2C9 revealed that this patient had a genotype CYP2C9*3/*4. This is the first Korean compound heterozygote for CYP2C9*3 and *4. This case suggests the clinical usefulness of pharmacogenetic testing for individualized dosage adjustments of warfarin. The Korean Academy of Medical Sciences 2007-06 2007-06-30 /pmc/articles/PMC2693655/ /pubmed/17596671 http://dx.doi.org/10.3346/jkms.2007.22.3.557 Text en Copyright © 2007 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Soo-Youn
Nam, Myung-Hyun
Kim, June Soo
Kim, Jong-Won
A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement
title A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement
title_full A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement
title_fullStr A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement
title_full_unstemmed A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement
title_short A Case Report of a Patient Carrying CYP2C9*3/4 Genotype with Extremely Low Warfarin Dose Requirement
title_sort case report of a patient carrying cyp2c9*3/4 genotype with extremely low warfarin dose requirement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693655/
https://www.ncbi.nlm.nih.gov/pubmed/17596671
http://dx.doi.org/10.3346/jkms.2007.22.3.557
work_keys_str_mv AT leesooyoun acasereportofapatientcarryingcyp2c934genotypewithextremelylowwarfarindoserequirement
AT nammyunghyun acasereportofapatientcarryingcyp2c934genotypewithextremelylowwarfarindoserequirement
AT kimjunesoo acasereportofapatientcarryingcyp2c934genotypewithextremelylowwarfarindoserequirement
AT kimjongwon acasereportofapatientcarryingcyp2c934genotypewithextremelylowwarfarindoserequirement
AT leesooyoun casereportofapatientcarryingcyp2c934genotypewithextremelylowwarfarindoserequirement
AT nammyunghyun casereportofapatientcarryingcyp2c934genotypewithextremelylowwarfarindoserequirement
AT kimjunesoo casereportofapatientcarryingcyp2c934genotypewithextremelylowwarfarindoserequirement
AT kimjongwon casereportofapatientcarryingcyp2c934genotypewithextremelylowwarfarindoserequirement

Ejemplares similares