Cargando…

Prion Protein Paralog Doppel Protein Interacts with Alpha-2-Macroglobulin: A Plausible Mechanism for Doppel-Mediated Neurodegeneration

Doppel protein (Dpl) is a paralog of the cellular form of the prion protein (PrP(C)), together sharing common structural and biochemical properties. Unlike PrP(C), which is abundantly expressed throughout the central nervous system (CNS), Dpl protein expression is not detectable in the CNS. Interest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Benvegnù, Stefano, Franciotta, Diego, Sussman, Josh, Bachi, Angela, Zardini, Elisabetta, Torreri, Paola, Govaerts, Cedric, Pizzo, Salvatore, Legname, Giuseppe
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693666/ https://www.ncbi.nlm.nih.gov/pubmed/19536284 http://dx.doi.org/10.1371/journal.pone.0005968

Ejemplares similares

Correction: Prion Protein Paralog Doppel Protein Interacts with Alpha-2-Macroglobulin: A Plausible Mechanism for Doppel-Mediated Neurodegeneration
por: Benvegnù, Stefano, et al.
Publicado: (2009)

Similar folds with different stabilization mechanisms: the cases of prion and doppel proteins
por: Colacino, Stefano, et al.
Publicado: (2006)

The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells
por: Didonna, Alessandro, et al.
Publicado: (2012)

Differential Responses of Neuronal and Spermatogenic Cells to the Doppel Cytotoxicity
por: Qin, Kefeng, et al.
Publicado: (2013)

Biochemical Signatures of Doppel Protein in Human Astrocytomas to Support Prediction in Tumor Malignancy
por: Rognoni, Paola, et al.
Publicado: (2010)

The doppel (Dpl) Protein Influences In Vitro Migration Capability in Astrocytoma-Derived Cells
por: Azzalin, Alberto, et al.
Publicado: (2008)

Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle
por: Brunelle, Brian W., et al.
Publicado: (2016)

Altered Cellular Distribution and Sub-Cellular Sorting of Doppel (Dpl) Protein in Human Astrocytoma Cell Lines
por: Sbalchiero, Elena, et al.
Publicado: (2008)

Doppel and PrP(C) co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells
por: Caputo, Anna, et al.
Publicado: (2009)

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration
por: Scialò, Carlo, et al.
Publicado: (2019)

Prion protein and aging
por: Gasperini, Lisa, et al.
Publicado: (2014)

Elucidating the function of the prion protein
por: Legname, Giuseppe
Publicado: (2017)

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins
por: Legname, Giuseppe
Publicado: (2023)

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection
por: Aguilar-Calvo, Patricia, et al.
Publicado: (2023)

Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases
por: Arnould, Hélène, et al.
Publicado: (2021)

Structural Consequences of Copper Binding to the Prion Protein
por: Salzano, Giulia, et al.
Publicado: (2019)

Prion-like spread of protein aggregates in neurodegeneration
por: Polymenidou, Magdalini, et al.
Publicado: (2012)

New insights into structural determinants of prion protein folding and stability
por: Benetti, Federico, et al.
Publicado: (2015)

Prion Protein-Specific Antibodies-Development, Modes of Action and Therapeutics Application
por: Rovis, Tihana Lenac, et al.
Publicado: (2014)

On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases
por: Legname, Giuseppe, et al.
Publicado: (2020)

Heterotypic transcriptional condensates formed by prion-like paralogous proteins canalize flowering transition in tomato
por: Huang, Xiaozhen, et al.
Publicado: (2022)

The Quest for Cellular Prion Protein Functions in the Aged and Neurodegenerating Brain
por: Gavín, Rosalina, et al.
Publicado: (2020)

Mapping the Prion Protein Distribution in Marsupials: Insights from Comparing Opossum with Mouse CNS
por: Poggiolini, Ilaria, et al.
Publicado: (2012)

Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy
por: Giachin, Gabriele, et al.
Publicado: (2013)

Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
por: Abskharon, Romany, et al.
Publicado: (2019)

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein
por: Rane, Neena S., et al.
Publicado: (2010)

Prion Protein Accumulation in Lipid Rafts of Mouse Aging Brain
por: Agostini, Federica, et al.
Publicado: (2013)

Prion Protein Interaction with Soil Humic Substances: Environmental Implications
por: Giachin, Gabriele, et al.
Publicado: (2014)

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion
por: Giachin, Gabriele, et al.
Publicado: (2015)

Prion Protein and Copper Cooperatively Protect Neurons by Modulating NMDA Receptor Through S-nitrosylation
por: Gasperini, Lisa, et al.
Publicado: (2015)

De novo prions
por: Benetti, Federico, et al.
Publicado: (2010)

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils
por: Scialò, Carlo, et al.
Publicado: (2021)

In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution
por: Gasperini, Lisa, et al.
Publicado: (2016)

Plausible Minimal Substrate for Erm Protein
por: Lee, Hak Jin, et al.
Publicado: (2020)

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration
por: Alibhai, James, et al.
Publicado: (2016)

Characterization of paralogous protein families in rice
por: Lin, Haining, et al.
Publicado: (2008)

Retinoblastoma Protein Paralogs and Tumor Suppression
por: Flores, Mauricio, et al.
Publicado: (2022)

Disease-associated protein seeding suggests a dissociation between misfolded protein accumulation and neurodegeneration in prion disease
por: Alibhai, James, et al.
Publicado: (2017)

Hypothesis: Paralog Formation from Progenitor Proteins and Paralog Mutagenesis Spur the Rapid Evolution of Telomere Binding Proteins
por: Lustig, Arthur J.
Publicado: (2016)

CLASSIFICATION OF MYELOMA PROTEINS, BENCE JONES PROTEINS, AND MACROGLOBULINS INTO TWO GROUPS ON THE BASIS OF COMMON ANTIGENIC CHARACTERS
por: Mannik, Mart, et al.
Publicado: (1962)

Cannot write session to /tmp/vufind_sessions/sess_6tp6gcj0nd0rur9la6n7itaulu