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Prion Protein Paralog Doppel Protein Interacts with Alpha-2-Macroglobulin: A Plausible Mechanism for Doppel-Mediated Neurodegeneration

Doppel protein (Dpl) is a paralog of the cellular form of the prion protein (PrP(C)), together sharing common structural and biochemical properties. Unlike PrP(C), which is abundantly expressed throughout the central nervous system (CNS), Dpl protein expression is not detectable in the CNS. Interest...

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Detalles Bibliográficos
Autores principales:	Benvegnù, Stefano, Franciotta, Diego, Sussman, Josh, Bachi, Angela, Zardini, Elisabetta, Torreri, Paola, Govaerts, Cedric, Pizzo, Salvatore, Legname, Giuseppe
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693666/ https://www.ncbi.nlm.nih.gov/pubmed/19536284 http://dx.doi.org/10.1371/journal.pone.0005968

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