Attenuated AMPA Receptor Expression Allows Glioblastoma Cell Survival in Glutamate-Rich Environment

BACKGROUND: Glioblastoma multiforme (GBM) cells secrete large amounts of glutamate that can trigger AMPA-type glutamate receptors (AMPARs). This commonly results in Na(+) and Ca(2+)-permeability and thereby in excitotoxic cell death of the surrounding neurons. Here we investigated how the GBM cells...

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Detalles Bibliográficos
Autores principales: van Vuurden, Dannis G., Yazdani, Maryam, Bosma, Ingeborg, Broekhuizen, Aart J. F., Postma, Tjeerd J., Heimans, Jan J., van der Valk, Paul, Aronica, Eleonora, Tannous, Bakhos A., Würdinger, Thomas, Kaspers, Gertjan J. L., Cloos, Jacqueline
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693929/
https://www.ncbi.nlm.nih.gov/pubmed/19536293
http://dx.doi.org/10.1371/journal.pone.0005953

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