Oxidative cyclization of alkenols with Oxone using a miniflow reactor

A miniflow system for oxidative cyclization of alkenols with Oxone was developed. Thus, the oxidative cyclization of (Z)- and (E)-alkenols in i-PrOH with an aqueous solution of Oxone proceeded smoothly and safely in a PTFE tube without any exogenous catalytic species, and was subsequently quenched i...

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Detalles Bibliográficos
Autores principales: Yamada, Yoichi M A, Torii, Kaoru, Uozumi, Yasuhiro
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693950/
https://www.ncbi.nlm.nih.gov/pubmed/19513188
http://dx.doi.org/10.3762/bjoc.5.18
Descripción
Sumario:A miniflow system for oxidative cyclization of alkenols with Oxone was developed. Thus, the oxidative cyclization of (Z)- and (E)-alkenols in i-PrOH with an aqueous solution of Oxone proceeded smoothly and safely in a PTFE tube without any exogenous catalytic species, and was subsequently quenched in a flow-reaction manner to afford the corresponding furanyl and pyranyl carbinols quantitatively within 5 or 10 min of residence time.

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