Quantitative determination of glycosaminoglycans in tears of diabetic patients

PURPOSE: To determine the amount of glycosaminoglycans (GAGs) in tears of patients with diabetic retinopathy (DR) and to compare it with normal subjects. METHODS: 38 patients with DR and 24 normal volunteers were included. Thirty subjects suffered from background diabetic retinopathy (BDR) and 8 fro...

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Detalles Bibliográficos
Autores principales: Moschos, Marilita M, Rouvas, Alexandros A, Papadimitriou, Spyridon, Kotsolis, Athanasios, Sitaras, Nikolaos, Apostolopoulos, Michael
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694000/
https://www.ncbi.nlm.nih.gov/pubmed/19668757
Descripción
Sumario:PURPOSE: To determine the amount of glycosaminoglycans (GAGs) in tears of patients with diabetic retinopathy (DR) and to compare it with normal subjects. METHODS: 38 patients with DR and 24 normal volunteers were included. Thirty subjects suffered from background diabetic retinopathy (BDR) and 8 from proliferate diabetic retinopathy (PDR). For the GAGs assay, the uronic carbazole reaction was used. RESULTS: The mean concentration of GAGs was significantly higher in patients with DR than in normal subjects. The GAGs concentration in patients with BDR or PDR was significantly higher than in normal subjects. CONCLUSION: The measurement of GAGs in tears of diabetic patients could be a tool in order to assess the stability or not of the disease.

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