Quantitative determination of glycosaminoglycans in tears of diabetic patients

PURPOSE: To determine the amount of glycosaminoglycans (GAGs) in tears of patients with diabetic retinopathy (DR) and to compare it with normal subjects. METHODS: 38 patients with DR and 24 normal volunteers were included. Thirty subjects suffered from background diabetic retinopathy (BDR) and 8 fro...

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Autores principales: Moschos, Marilita M, Rouvas, Alexandros A, Papadimitriou, Spyridon, Kotsolis, Athanasios, Sitaras, Nikolaos, Apostolopoulos, Michael
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694000/
https://www.ncbi.nlm.nih.gov/pubmed/19668757
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author Moschos, Marilita M
Rouvas, Alexandros A
Papadimitriou, Spyridon
Kotsolis, Athanasios
Sitaras, Nikolaos
Apostolopoulos, Michael
author_facet Moschos, Marilita M
Rouvas, Alexandros A
Papadimitriou, Spyridon
Kotsolis, Athanasios
Sitaras, Nikolaos
Apostolopoulos, Michael
author_sort Moschos, Marilita M
collection PubMed
description PURPOSE: To determine the amount of glycosaminoglycans (GAGs) in tears of patients with diabetic retinopathy (DR) and to compare it with normal subjects. METHODS: 38 patients with DR and 24 normal volunteers were included. Thirty subjects suffered from background diabetic retinopathy (BDR) and 8 from proliferate diabetic retinopathy (PDR). For the GAGs assay, the uronic carbazole reaction was used. RESULTS: The mean concentration of GAGs was significantly higher in patients with DR than in normal subjects. The GAGs concentration in patients with BDR or PDR was significantly higher than in normal subjects. CONCLUSION: The measurement of GAGs in tears of diabetic patients could be a tool in order to assess the stability or not of the disease.
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spelling pubmed-26940002009-08-10 Quantitative determination of glycosaminoglycans in tears of diabetic patients Moschos, Marilita M Rouvas, Alexandros A Papadimitriou, Spyridon Kotsolis, Athanasios Sitaras, Nikolaos Apostolopoulos, Michael Clin Ophthalmol Original Research PURPOSE: To determine the amount of glycosaminoglycans (GAGs) in tears of patients with diabetic retinopathy (DR) and to compare it with normal subjects. METHODS: 38 patients with DR and 24 normal volunteers were included. Thirty subjects suffered from background diabetic retinopathy (BDR) and 8 from proliferate diabetic retinopathy (PDR). For the GAGs assay, the uronic carbazole reaction was used. RESULTS: The mean concentration of GAGs was significantly higher in patients with DR than in normal subjects. The GAGs concentration in patients with BDR or PDR was significantly higher than in normal subjects. CONCLUSION: The measurement of GAGs in tears of diabetic patients could be a tool in order to assess the stability or not of the disease. Dove Medical Press 2008-09 /pmc/articles/PMC2694000/ /pubmed/19668757 Text en © 2008 Moschos et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Moschos, Marilita M
Rouvas, Alexandros A
Papadimitriou, Spyridon
Kotsolis, Athanasios
Sitaras, Nikolaos
Apostolopoulos, Michael
Quantitative determination of glycosaminoglycans in tears of diabetic patients
title Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_full Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_fullStr Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_full_unstemmed Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_short Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_sort quantitative determination of glycosaminoglycans in tears of diabetic patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694000/
https://www.ncbi.nlm.nih.gov/pubmed/19668757
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