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Thrombophilic screening in retinal artery occlusion patients

BACKGROUND: Retinal artery occlusion (RAO) is an ischemic vascular damage of the retina, which frequently leads to sudden, mostly irreversible loss of vision. In this study, blood thrombophilic factors as well as cardiovascular risk factors were investigated for their relevance to this pathology. Th...

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Autores principales: Nagy, Valeria, Takacs, Lili, Steiber, Zita, Pfliegler, György, Berta, Andras
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694013/
https://www.ncbi.nlm.nih.gov/pubmed/19668753
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author Nagy, Valeria
Takacs, Lili
Steiber, Zita
Pfliegler, György
Berta, Andras
author_facet Nagy, Valeria
Takacs, Lili
Steiber, Zita
Pfliegler, György
Berta, Andras
author_sort Nagy, Valeria
collection PubMed
description BACKGROUND: Retinal artery occlusion (RAO) is an ischemic vascular damage of the retina, which frequently leads to sudden, mostly irreversible loss of vision. In this study, blood thrombophilic factors as well as cardiovascular risk factors were investigated for their relevance to this pathology. Thrombophilic risk factors so far not evaluated were included in the study. PATIENTS AND METHODS: 28 RAO patients and 81 matched control subjects were examined. From blood samples, protein C, protein S, antithrombinopathy, and factor V (Leiden) mutation (FV), factor II gene polymorphism, factor VIIIC level, plasminogen activity, lipoprotein(a) and fibrinogen levels, hyperhomocysteinemia and presence of anticardiolipin – antiphospholipid antibodies were investigated. Possibly relevant pathologies such as diabetes mellitus, hypertension, and ischemic heart disease were also registered. Statistical analysis by logistic regression was performed with 95% confidence intervals. RESULTS: In the group of patients with RAO only the incidence of hypertension (OR: 3.33, 95% CI: 1.30–9.70, p = 0.014) as an average risk factor showed significant difference, but thrombophilic factors such as hyperfibrinogenemia (OR: 2.9, 95% CI: 1.29–6.57, p = 0.010) and the presence of FV (Leiden mutation) (OR: 3.9, 95% CI: 1.43–10.96, p = 0.008) increased the chances of developing this disease. CONCLUSIONS: Our results support the assumption that thrombophilia may contribute to the development of RAO besides vascular damage due to the presence of cardiovascular risk factors. Further studies are needed, however, to justify the possible use of secondary prophylaxis in form of anticoagulant/antiplatelet therapy.
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spelling pubmed-26940132009-08-10 Thrombophilic screening in retinal artery occlusion patients Nagy, Valeria Takacs, Lili Steiber, Zita Pfliegler, György Berta, Andras Clin Ophthalmol Original Research BACKGROUND: Retinal artery occlusion (RAO) is an ischemic vascular damage of the retina, which frequently leads to sudden, mostly irreversible loss of vision. In this study, blood thrombophilic factors as well as cardiovascular risk factors were investigated for their relevance to this pathology. Thrombophilic risk factors so far not evaluated were included in the study. PATIENTS AND METHODS: 28 RAO patients and 81 matched control subjects were examined. From blood samples, protein C, protein S, antithrombinopathy, and factor V (Leiden) mutation (FV), factor II gene polymorphism, factor VIIIC level, plasminogen activity, lipoprotein(a) and fibrinogen levels, hyperhomocysteinemia and presence of anticardiolipin – antiphospholipid antibodies were investigated. Possibly relevant pathologies such as diabetes mellitus, hypertension, and ischemic heart disease were also registered. Statistical analysis by logistic regression was performed with 95% confidence intervals. RESULTS: In the group of patients with RAO only the incidence of hypertension (OR: 3.33, 95% CI: 1.30–9.70, p = 0.014) as an average risk factor showed significant difference, but thrombophilic factors such as hyperfibrinogenemia (OR: 2.9, 95% CI: 1.29–6.57, p = 0.010) and the presence of FV (Leiden mutation) (OR: 3.9, 95% CI: 1.43–10.96, p = 0.008) increased the chances of developing this disease. CONCLUSIONS: Our results support the assumption that thrombophilia may contribute to the development of RAO besides vascular damage due to the presence of cardiovascular risk factors. Further studies are needed, however, to justify the possible use of secondary prophylaxis in form of anticoagulant/antiplatelet therapy. Dove Medical Press 2008-09 /pmc/articles/PMC2694013/ /pubmed/19668753 Text en © 2008 Dove Medical Press Limited. All rights reserved
spellingShingle Original Research
Nagy, Valeria
Takacs, Lili
Steiber, Zita
Pfliegler, György
Berta, Andras
Thrombophilic screening in retinal artery occlusion patients
title Thrombophilic screening in retinal artery occlusion patients
title_full Thrombophilic screening in retinal artery occlusion patients
title_fullStr Thrombophilic screening in retinal artery occlusion patients
title_full_unstemmed Thrombophilic screening in retinal artery occlusion patients
title_short Thrombophilic screening in retinal artery occlusion patients
title_sort thrombophilic screening in retinal artery occlusion patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694013/
https://www.ncbi.nlm.nih.gov/pubmed/19668753
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