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Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study

It is well established that the ingestion of the omega-3 (N3) fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) positively benefit a variety of health indices. Despite these benefits the actual intake of fish derived N3 is relatively small in the United States. The primary aim o...

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Autores principales: Earnest, Conrad P, Hammar, Molly K, Munsey, Monica, Mikus, Catherine R, David, Robert M, Bralley, J Alexander, Church, Timothy S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694142/
https://www.ncbi.nlm.nih.gov/pubmed/19480650
http://dx.doi.org/10.1186/1550-2783-6-12
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author Earnest, Conrad P
Hammar, Molly K
Munsey, Monica
Mikus, Catherine R
David, Robert M
Bralley, J Alexander
Church, Timothy S
author_facet Earnest, Conrad P
Hammar, Molly K
Munsey, Monica
Mikus, Catherine R
David, Robert M
Bralley, J Alexander
Church, Timothy S
author_sort Earnest, Conrad P
collection PubMed
description It is well established that the ingestion of the omega-3 (N3) fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) positively benefit a variety of health indices. Despite these benefits the actual intake of fish derived N3 is relatively small in the United States. The primary aim of our study was to examine a technology capable of delivering omega-3 fatty acids in common foods via microencapsulation (MicroN3) in young, healthy, active participants who are at low risk for cardiovascular disease. Accordingly, we randomized 20 participants (25.4 ± 6.2 y; 73.4 ± 5.1 kg) to receive the double blind delivery of a placebo-matched breakfast meal (~2093 kJ) containing MicroN3 (450–550 mg EPA/DHA) during a 2-week pilot trial. Overall, we observed no differences in overall dietary macronutrient intake other than the N3 delivery during our treatment regimen. Post-test ANOVA analysis showed a significant elevation in mean (SE) plasma DHA (91.18 ± 9.3 vs. 125.58 ± 11.3 umol/L; P < 0.05) and a reduction in triacylglycerols (89.89 ± 12.8 vs. 80.78 ± 10.4 mg/dL; P < 0.05) accompanying the MicroN3 treatment that was significantly different from placebo (P < 0.05). In post study interviews, participants reported that the ingested food was well-tolerated, contained no fish taste, odor or gastrointestinal distress accompanying treatment. The use of MicroN3 foods provides a novel delivery system for the delivery of essential fatty acids. Our study demonstrates that MicroN3 foods promote the absorption of essential N3, demonstrate bioactivity within 2 weeks of ingestion and are well tolerated in young, active participants who are at low risk for cardiovascular disease.
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spelling pubmed-26941422009-06-09 Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study Earnest, Conrad P Hammar, Molly K Munsey, Monica Mikus, Catherine R David, Robert M Bralley, J Alexander Church, Timothy S J Int Soc Sports Nutr Short Reports It is well established that the ingestion of the omega-3 (N3) fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) positively benefit a variety of health indices. Despite these benefits the actual intake of fish derived N3 is relatively small in the United States. The primary aim of our study was to examine a technology capable of delivering omega-3 fatty acids in common foods via microencapsulation (MicroN3) in young, healthy, active participants who are at low risk for cardiovascular disease. Accordingly, we randomized 20 participants (25.4 ± 6.2 y; 73.4 ± 5.1 kg) to receive the double blind delivery of a placebo-matched breakfast meal (~2093 kJ) containing MicroN3 (450–550 mg EPA/DHA) during a 2-week pilot trial. Overall, we observed no differences in overall dietary macronutrient intake other than the N3 delivery during our treatment regimen. Post-test ANOVA analysis showed a significant elevation in mean (SE) plasma DHA (91.18 ± 9.3 vs. 125.58 ± 11.3 umol/L; P < 0.05) and a reduction in triacylglycerols (89.89 ± 12.8 vs. 80.78 ± 10.4 mg/dL; P < 0.05) accompanying the MicroN3 treatment that was significantly different from placebo (P < 0.05). In post study interviews, participants reported that the ingested food was well-tolerated, contained no fish taste, odor or gastrointestinal distress accompanying treatment. The use of MicroN3 foods provides a novel delivery system for the delivery of essential fatty acids. Our study demonstrates that MicroN3 foods promote the absorption of essential N3, demonstrate bioactivity within 2 weeks of ingestion and are well tolerated in young, active participants who are at low risk for cardiovascular disease. BioMed Central 2009-05-29 /pmc/articles/PMC2694142/ /pubmed/19480650 http://dx.doi.org/10.1186/1550-2783-6-12 Text en Copyright © 2009 Earnest et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Earnest, Conrad P
Hammar, Molly K
Munsey, Monica
Mikus, Catherine R
David, Robert M
Bralley, J Alexander
Church, Timothy S
Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study
title Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study
title_full Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study
title_fullStr Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study
title_full_unstemmed Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study
title_short Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study
title_sort microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694142/
https://www.ncbi.nlm.nih.gov/pubmed/19480650
http://dx.doi.org/10.1186/1550-2783-6-12
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