Cargando…

A superior drug carrier – aponeocarzinostatin in partially unfolded state fully protects the labile antitumor enediyne

BACKGROUND: Neocarzinostatin is a potent antitumor drug consisting of an enediyne chromophore and a protein carrier. METHODS: We characterized an intermediate in the equilibrium unfolding pathway of aponeocarzinostatin, using a variety of biophysical techniques including 1-anilino-8-napthalene sulfo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shanmuganathan, Aranganathan, Kumar, Thallapuranam Krishnaswamy Suresh, Huang, Chiy-Mey, Yu, Chin, Chin, Der-Hang
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694159/ https://www.ncbi.nlm.nih.gov/pubmed/19463188 http://dx.doi.org/10.1186/1423-0127-16-48

Ejemplares similares

Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor
por: Agrawal, Shilpi, et al.
Publicado: (2021)

Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027
por: Chen, Yihua, et al.
Publicado: (2010)

Alkoxy and Enediyne Derivatives Containing 1,4-Benzoquinone Subunits—Synthesis and Antitumor Activity
por: Kadela-Tomanek, Monika, et al.
Publicado: (2017)

A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products
por: Bhardwaj, Minakshi, et al.
Publicado: (2023)

Discovery of pentaene polyols by the activation of an enediyne gene cluster: biosynthetic implications for 9-membered enediyne core structures
por: Pan, Jian, et al.
Publicado: (2022)

Enediyne Polyketide Synthases Stereoselectively Reduce the β-Ketoacyl Intermediates to β-d-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis
por: Ge, Hui-Ming, et al.
Publicado: (2014)

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus
por: Chang, Chin-Yuan, et al.
Publicado: (2016)

Correction for Bhardwaj et al., A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products
Publicado: (2023)

Crystal Structure of SgcJ, An NTF2-Like Superfamily Protein Involved in Biosynthesis of the 9-Membered Enediyne Antitumor Antibiotic C-1027
por: Huang, Tingting, et al.
Publicado: (2016)

An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy
por: Xu, Jian, et al.
Publicado: (2015)

A novel enediyne‐integrated antibody–drug conjugate shows promising antitumor efficacy against CD30(+) lymphomas
por: Wang, Rong, et al.
Publicado: (2018)

Strain Prioritization and Genome Mining for Enediyne Natural Products
por: Yan, Xiaohui, et al.
Publicado: (2016)

Thermal Reactivity of Neutral and Oxidized Ferrocenyl-Substituted Enediynes
por: Cinar, Mehmet Emin, et al.
Publicado: (2014)

Cross-π-conjugated enediyne with multitopic metal binding sites
por: Nauroozi, Djawed, et al.
Publicado: (2020)

Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study
por: Prudovsky, Igor, et al.
Publicado: (2013)

Amyloidogenesis: What Do We Know So Far?
por: Alraawi, Zeina, et al.
Publicado: (2022)

Highly stereocontrolled synthesis of trans-enediynes via carbocupration of fluoroalkylated diynes
por: Konno, Tsutomu, et al.
Publicado: (2012)

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads
por: Shen, Ben, et al.
Publicado: (2014)

Lysosome Labilizers Potentiate the Antitumor Effects of Tumor Necrosis Factor‐α
por: Masegi, Tsukio, et al.
Publicado: (1993)

A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
por: Cohen, Douglas R., et al.
Publicado: (2017)

Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates
por: Adhikari, Ajeeth, et al.
Publicado: (2021)

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis
por: Annaval, Thibault, et al.
Publicado: (2017)

Jejucarbosides B–E, Chlorinated Cycloaromatized Enediynes, from a Marine Streptomyces sp.
por: Im, Ji Hyeon, et al.
Publicado: (2023)

Ruthenium-Catalyzed Intramolecular [2+2+2] Cycloaddition and Tandem Cross-Metathesis of Triynes and Enediynes
por: Yuan, Wei, et al.
Publicado: (2013)

Angle distortion model for predicting enediyne activation towards Bergman cyclization: an alternate to the distance theory
por: Bhattacharya, Prabuddha, et al.
Publicado: (2022)

Rhodium-catalysed tetradehydro-Diels–Alder reactions of enediynes via a rhodium-stabilized cyclic allene
por: Thadkapally, Srinivas, et al.
Publicado: (2020)

Nucleophilic Addition of Enolates to 1,4-Dehydrobenzene Diradicals Derived from Enediynes: Synthesis of Functionalized Aromatics
por: Shrinidhi, Annadka, et al.
Publicado: (2022)

The Saga of Endocrine FGFs
por: Phan, Phuc, et al.
Publicado: (2021)

An EGFR/HER2-Bispecific and Enediyne-Energized Fusion Protein Shows High Efficacy against Esophageal Cancer
por: Guo, Xiao-Fang, et al.
Publicado: (2014)

Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S
por: Zhu, Manxiang, et al.
Publicado: (2022)

Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila
por: Sen, Aditya, et al.
Publicado: (2016)

A Janus-faced role of the unfolded protein response in antitumor immunity
por: Mahadevan, Navin R., et al.
Publicado: (2013)

Alkali-labile gangliosides
por: Mauri, Laura, et al.
Publicado: (2023)

Zeolites as Carriers of Antitumor Ribonuclease Binase
por: Khojaewa, Vera, et al.
Publicado: (2019)

Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027
por: Wang, Lifei, et al.
Publicado: (2009)

Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19
por: Elshahawi, Sherif I., et al.
Publicado: (2014)

The Role of Norrish Type-I Chemistry in Photoactive Drugs: An ab initio Study of a Cyclopropenone-Enediyne Drug Precursor
por: Léger, Spencer J., et al.
Publicado: (2020)

MSFragger-Labile: A Flexible Method to Improve Labile PTM Analysis in Proteomics
por: Polasky, Daniel A., et al.
Publicado: (2023)

cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach
por: Benton, Mitchell, et al.
Publicado: (2023)

Modulation of Interleukin-12 activity in the presence of heparin
por: Jayanthi, Srinivas, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6qgs8avalcermuqbacd1j70h1t