Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice

BACKGROUND: The immune mechanisms associated with infection-induced disease exacerbations in asthma and COPD are not fully understood. Toll-like receptor (TLR) 3 has an important role in recognition of double-stranded viral RNA, which leads to the production of various inflammatory mediators. Thus,...

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Detalles Bibliográficos
Autores principales: Stowell, Nicole C, Seideman, Jonathan, Raymond, Holly A, Smalley, Karen A, Lamb, Roberta J, Egenolf, Devon D, Bugelski, Peter J, Murray, Lynne A, Marsters, Paul A, Bunting, Rachel A, Flavell, Richard A, Alexopoulou, Lena, San Mateo, Lani R, Griswold, Don E, Sarisky, Robert T, Mbow, M Lamine, Das, Anuk M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694181/
https://www.ncbi.nlm.nih.gov/pubmed/19486528
http://dx.doi.org/10.1186/1465-9921-10-43

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