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Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results

BACKGROUND: In stereotactic body radiotherapy (SBRT) for lung tumors, reducing tumor movement is necessary. In this study, we evaluated changes in tumor movement and percutaneous oxygen saturation (SpO(2)) levels, and preliminary clinical results of SBRT using the BodyFIX immobilization system. METH...

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Autores principales: Baba, Fumiya, Shibamoto, Yuta, Tomita, Natsuo, Ikeya-Hashizume, Chisa, Oda, Kyota, Ayakawa, Shiho, Ogino, Hiroyuki, Sugie, Chikao
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694202/
https://www.ncbi.nlm.nih.gov/pubmed/19476628
http://dx.doi.org/10.1186/1748-717X-4-15
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author Baba, Fumiya
Shibamoto, Yuta
Tomita, Natsuo
Ikeya-Hashizume, Chisa
Oda, Kyota
Ayakawa, Shiho
Ogino, Hiroyuki
Sugie, Chikao
author_facet Baba, Fumiya
Shibamoto, Yuta
Tomita, Natsuo
Ikeya-Hashizume, Chisa
Oda, Kyota
Ayakawa, Shiho
Ogino, Hiroyuki
Sugie, Chikao
author_sort Baba, Fumiya
collection PubMed
description BACKGROUND: In stereotactic body radiotherapy (SBRT) for lung tumors, reducing tumor movement is necessary. In this study, we evaluated changes in tumor movement and percutaneous oxygen saturation (SpO(2)) levels, and preliminary clinical results of SBRT using the BodyFIX immobilization system. METHODS: Between 2004 and 2006, 53 consecutive patients were treated for 55 lesions; 42 were stage I non-small cell lung cancer (NSCLC), 10 were metastatic lung cancers, and 3 were local recurrences of NSCLC. Tumor movement was measured with fluoroscopy under breath holding, free breathing on a couch, and free breathing in the BodyFIX system. SpO(2 )levels were measured with a finger pulseoximeter under each condition. The delivered dose was 44, 48 or 52 Gy, depending on tumor diameter, in 4 fractions over 10 or 11 days. RESULTS: By using the BodyFIX system, respiratory tumor movements were significantly reduced compared with the free-breathing condition in both craniocaudal and lateral directions, although the amplitude of reduction in the craniocaudal direction was 3 mm or more in only 27% of the patients. The average SpO(2 )did not decrease by using the system. At 3 years, the local control rate was 80% for all lesions. Overall survival was 76%, cause-specific survival was 92%, and local progression-free survival was 76% at 3 years in primary NSCLC patients. Grade 2 radiation pneumonitis developed in 7 patients. CONCLUSION: Respiratory tumor movement was modestly suppressed by the BodyFIX system, while the SpO(2 )level did not decrease. It was considered a simple and effective method for SBRT of lung tumors. Preliminary results were encouraging.
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spelling pubmed-26942022009-06-09 Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results Baba, Fumiya Shibamoto, Yuta Tomita, Natsuo Ikeya-Hashizume, Chisa Oda, Kyota Ayakawa, Shiho Ogino, Hiroyuki Sugie, Chikao Radiat Oncol Research BACKGROUND: In stereotactic body radiotherapy (SBRT) for lung tumors, reducing tumor movement is necessary. In this study, we evaluated changes in tumor movement and percutaneous oxygen saturation (SpO(2)) levels, and preliminary clinical results of SBRT using the BodyFIX immobilization system. METHODS: Between 2004 and 2006, 53 consecutive patients were treated for 55 lesions; 42 were stage I non-small cell lung cancer (NSCLC), 10 were metastatic lung cancers, and 3 were local recurrences of NSCLC. Tumor movement was measured with fluoroscopy under breath holding, free breathing on a couch, and free breathing in the BodyFIX system. SpO(2 )levels were measured with a finger pulseoximeter under each condition. The delivered dose was 44, 48 or 52 Gy, depending on tumor diameter, in 4 fractions over 10 or 11 days. RESULTS: By using the BodyFIX system, respiratory tumor movements were significantly reduced compared with the free-breathing condition in both craniocaudal and lateral directions, although the amplitude of reduction in the craniocaudal direction was 3 mm or more in only 27% of the patients. The average SpO(2 )did not decrease by using the system. At 3 years, the local control rate was 80% for all lesions. Overall survival was 76%, cause-specific survival was 92%, and local progression-free survival was 76% at 3 years in primary NSCLC patients. Grade 2 radiation pneumonitis developed in 7 patients. CONCLUSION: Respiratory tumor movement was modestly suppressed by the BodyFIX system, while the SpO(2 )level did not decrease. It was considered a simple and effective method for SBRT of lung tumors. Preliminary results were encouraging. BioMed Central 2009-05-28 /pmc/articles/PMC2694202/ /pubmed/19476628 http://dx.doi.org/10.1186/1748-717X-4-15 Text en Copyright © 2009 Baba et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Baba, Fumiya
Shibamoto, Yuta
Tomita, Natsuo
Ikeya-Hashizume, Chisa
Oda, Kyota
Ayakawa, Shiho
Ogino, Hiroyuki
Sugie, Chikao
Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results
title Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results
title_full Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results
title_fullStr Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results
title_full_unstemmed Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results
title_short Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results
title_sort stereotactic body radiotherapy for stage i lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694202/
https://www.ncbi.nlm.nih.gov/pubmed/19476628
http://dx.doi.org/10.1186/1748-717X-4-15
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