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Regulation of LRRK2 Stability by the E3 Ubiquitin Ligase CHIP
Dominantly inherited mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common cause of familial Parkinson's disease (PD) and have also been identified in individuals with sporadic PD. Although the exact cellular function of LRRK2 remains unknown, most PD-linked mutations a...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694275/ https://www.ncbi.nlm.nih.gov/pubmed/19536328 http://dx.doi.org/10.1371/journal.pone.0005949 |