Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target

BACKGROUND: Ewing sarcoma is a paradigm of solid tumour -bearing chromosomal translocations resulting in fusion proteins that act as deregulated transcription factors. Ewing sarcoma translocations fuse the EWS gene with an ETS transcription factor, mainly FLI1. Most of the EWS–FLI1 target genes stil...

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Detalles Bibliográficos
Autores principales: Herrero-Martín, D, Osuna, D, Ordóñez, J L, Sevillano, V, Martins, A S, Mackintosh, C, Campos, M, Madoz-Gúrpide, J, Otero-Motta, A P, Caballero, G, Amaral, A T, Wai, D H, Braun, Y, Eisenacher, M, Schaefer, K-L, Poremba, C, de Alava, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694277/
https://www.ncbi.nlm.nih.gov/pubmed/19491900
http://dx.doi.org/10.1038/sj.bjc.6605104

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