Experimental rat bladder urothelial cell carcinoma models

Bladder cancer is a major public health problem. Currently available therapeutic options seem to be unable to prevent bladder cancer recurrence and progression. To enable preclinical testing of new intravesical therapeutic agents, a suitable bladder tumor model that resembles human disease is highly...

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Detalles Bibliográficos
Autores principales: Arentsen, Harm C., Hendricksen, Kees, Oosterwijk, Egbert, Witjes, J. Alfred
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Topic Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694312/
https://www.ncbi.nlm.nih.gov/pubmed/19219611
http://dx.doi.org/10.1007/s00345-009-0381-5
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author Arentsen, Harm C.
Hendricksen, Kees
Oosterwijk, Egbert
Witjes, J. Alfred
author_facet Arentsen, Harm C.
Hendricksen, Kees
Oosterwijk, Egbert
Witjes, J. Alfred
author_sort Arentsen, Harm C.
collection PubMed
description Bladder cancer is a major public health problem. Currently available therapeutic options seem to be unable to prevent bladder cancer recurrence and progression. To enable preclinical testing of new intravesical therapeutic agents, a suitable bladder tumor model that resembles human disease is highly desirable. The aim of this topic paper was to discuss the problems associated with current in vivo animal bladder tumor models, focusing on the orthotopic syngeneic rat bladder tumor model. In the second part of the paper the development of a potential new orthotopic rat bladder tumor model is described.
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spelling pubmed-26943122009-06-16 Experimental rat bladder urothelial cell carcinoma models Arentsen, Harm C. Hendricksen, Kees Oosterwijk, Egbert Witjes, J. Alfred World J Urol Topic Paper Bladder cancer is a major public health problem. Currently available therapeutic options seem to be unable to prevent bladder cancer recurrence and progression. To enable preclinical testing of new intravesical therapeutic agents, a suitable bladder tumor model that resembles human disease is highly desirable. The aim of this topic paper was to discuss the problems associated with current in vivo animal bladder tumor models, focusing on the orthotopic syngeneic rat bladder tumor model. In the second part of the paper the development of a potential new orthotopic rat bladder tumor model is described. Springer-Verlag 2009-02-15 2009-06 /pmc/articles/PMC2694312/ /pubmed/19219611 http://dx.doi.org/10.1007/s00345-009-0381-5 Text en © The Author(s) 2009
spellingShingle Topic Paper
Arentsen, Harm C.
Hendricksen, Kees
Oosterwijk, Egbert
Witjes, J. Alfred
Experimental rat bladder urothelial cell carcinoma models
title Experimental rat bladder urothelial cell carcinoma models
title_full Experimental rat bladder urothelial cell carcinoma models
title_fullStr Experimental rat bladder urothelial cell carcinoma models
title_full_unstemmed Experimental rat bladder urothelial cell carcinoma models
title_short Experimental rat bladder urothelial cell carcinoma models
title_sort experimental rat bladder urothelial cell carcinoma models
topic Topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694312/
https://www.ncbi.nlm.nih.gov/pubmed/19219611
http://dx.doi.org/10.1007/s00345-009-0381-5
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AT witjesjalfred experimentalratbladderurothelialcellcarcinomamodels

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