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The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice
We examined mechanisms by which L-4F reduces obesity and diabetes in obese (ob) diabetic mice. We hypothesized that L-4F reduces adiposity via increased pAMPK, pAKT, HO-1, and increased insulin receptor phosphorylation in ob mice. Obese and lean mice were divided into five groups: lean, lean-L-4F-tr...
Autores principales: | Peterson, Stephen J., Kim, Dong Hyun, Li, Ming, Positano, Vincenzo, Vanella, Luca, Rodella, Luigi F., Piccolomini, Francesco, Puri, Nitin, Gastaldelli, Amalia, Kusmic, Claudia, L'Abbate, Antonio, Abraham, Nader G. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694329/ https://www.ncbi.nlm.nih.gov/pubmed/19224872 http://dx.doi.org/10.1194/jlr.M800610-JLR200 |
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