Preclinical Evaluation of a Replication-Deficient Intranasal ΔNS1 H5N1 Influenza Vaccine

BACKGROUND: We developed a novel intranasal influenza vaccine approach that is based on the construction of replication-deficient vaccine viruses that lack the entire NS1 gene (ΔNS1 virus). We previously showed that these viruses undergo abortive replication in the respiratory tract of animals. The...

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Detalles Bibliográficos
Autores principales: Romanova, Julia, Krenn, Brigitte M., Wolschek, Markus, Ferko, Boris, Romanovskaja-Romanko, Ekaterina, Morokutti, Alexander, Shurygina, Anna-Polina, Nakowitsch, Sabine, Ruthsatz, Tanja, Kiefmann, Bettina, König, Ulrich, Bergmann, Michael, Sachet, Monika, Balasingam, Shobana, Mann, Alexander, Oxford, John, Slais, Martin, Kiselev, Oleg, Muster, Thomas, Egorov, Andrej
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694350/
https://www.ncbi.nlm.nih.gov/pubmed/19543385
http://dx.doi.org/10.1371/journal.pone.0005984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694350/
https://www.ncbi.nlm.nih.gov/pubmed/19543385
http://dx.doi.org/10.1371/journal.pone.0005984

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