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Preclinical Evaluation of a Replication-Deficient Intranasal ΔNS1 H5N1 Influenza Vaccine
BACKGROUND: We developed a novel intranasal influenza vaccine approach that is based on the construction of replication-deficient vaccine viruses that lack the entire NS1 gene (ΔNS1 virus). We previously showed that these viruses undergo abortive replication in the respiratory tract of animals. The...
Autores principales: | Romanova, Julia, Krenn, Brigitte M., Wolschek, Markus, Ferko, Boris, Romanovskaja-Romanko, Ekaterina, Morokutti, Alexander, Shurygina, Anna-Polina, Nakowitsch, Sabine, Ruthsatz, Tanja, Kiefmann, Bettina, König, Ulrich, Bergmann, Michael, Sachet, Monika, Balasingam, Shobana, Mann, Alexander, Oxford, John, Slais, Martin, Kiselev, Oleg, Muster, Thomas, Egorov, Andrej |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694350/ https://www.ncbi.nlm.nih.gov/pubmed/19543385 http://dx.doi.org/10.1371/journal.pone.0005984 |
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