De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in d...

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Detalles Bibliográficos
Autores principales: Mashima, T, Seimiya, H, Tsuruo, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694429/
https://www.ncbi.nlm.nih.gov/pubmed/19352381
http://dx.doi.org/10.1038/sj.bjc.6605007
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author Mashima, T
Seimiya, H
Tsuruo, T
author_facet Mashima, T
Seimiya, H
Tsuruo, T
author_sort Mashima, T
collection PubMed
description Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways.
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spelling pubmed-26944292010-05-05 De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy Mashima, T Seimiya, H Tsuruo, T Br J Cancer Minireview Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways. Nature Publishing Group 2009-05-05 2009-04-07 /pmc/articles/PMC2694429/ /pubmed/19352381 http://dx.doi.org/10.1038/sj.bjc.6605007 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Mashima, T
Seimiya, H
Tsuruo, T
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
title De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
title_full De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
title_fullStr De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
title_full_unstemmed De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
title_short De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
title_sort de novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694429/
https://www.ncbi.nlm.nih.gov/pubmed/19352381
http://dx.doi.org/10.1038/sj.bjc.6605007
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AT seimiyah denovofattyacidsynthesisandrelatedpathwaysasmoleculartargetsforcancertherapy
AT tsuruot denovofattyacidsynthesisandrelatedpathwaysasmoleculartargetsforcancertherapy

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