Lack of complex I is associated with oncocytic thyroid tumours

Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrou...

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Detalles Bibliográficos
Autores principales: Zimmermann, F A, Mayr, J A, Neureiter, D, Feichtinger, R, Alinger, B, Jones, N D, Eder, W, Sperl, W, Kofler, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694433/
https://www.ncbi.nlm.nih.gov/pubmed/19352385
http://dx.doi.org/10.1038/sj.bjc.6605028
Descripción
Sumario:Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.

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