Lack of complex I is associated with oncocytic thyroid tumours

Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrou...

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Autores principales: Zimmermann, F A, Mayr, J A, Neureiter, D, Feichtinger, R, Alinger, B, Jones, N D, Eder, W, Sperl, W, Kofler, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694433/
https://www.ncbi.nlm.nih.gov/pubmed/19352385
http://dx.doi.org/10.1038/sj.bjc.6605028
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author Zimmermann, F A
Mayr, J A
Neureiter, D
Feichtinger, R
Alinger, B
Jones, N D
Eder, W
Sperl, W
Kofler, B
author_facet Zimmermann, F A
Mayr, J A
Neureiter, D
Feichtinger, R
Alinger, B
Jones, N D
Eder, W
Sperl, W
Kofler, B
author_sort Zimmermann, F A
collection PubMed
description Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.
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spelling pubmed-26944332010-05-05 Lack of complex I is associated with oncocytic thyroid tumours Zimmermann, F A Mayr, J A Neureiter, D Feichtinger, R Alinger, B Jones, N D Eder, W Sperl, W Kofler, B Br J Cancer Short Communication Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue. Nature Publishing Group 2009-05-05 2009-04-07 /pmc/articles/PMC2694433/ /pubmed/19352385 http://dx.doi.org/10.1038/sj.bjc.6605028 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Zimmermann, F A
Mayr, J A
Neureiter, D
Feichtinger, R
Alinger, B
Jones, N D
Eder, W
Sperl, W
Kofler, B
Lack of complex I is associated with oncocytic thyroid tumours
title Lack of complex I is associated with oncocytic thyroid tumours
title_full Lack of complex I is associated with oncocytic thyroid tumours
title_fullStr Lack of complex I is associated with oncocytic thyroid tumours
title_full_unstemmed Lack of complex I is associated with oncocytic thyroid tumours
title_short Lack of complex I is associated with oncocytic thyroid tumours
title_sort lack of complex i is associated with oncocytic thyroid tumours
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694433/
https://www.ncbi.nlm.nih.gov/pubmed/19352385
http://dx.doi.org/10.1038/sj.bjc.6605028
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