Is adiponectin associated with acute myocardial infarction in Iranian non obese patients?

BACKGROUNDS: Adiponectin is an adipose tissue-derived mediator with significant anti-atherogenic properties. A few studies were done in acute phase of myocardial infarction especially in non obese patients. We design a study to investigate the association between adiponectin concentration and acute phase of myocardial infarction in non obese patients. METHODS: This case-control study was done in Paymaneah Hospital (Jahrom, Iran) from Feb 2007 to May 2008. Plasma adiponectin levels were measured in 43 patients with AMI (mean age: 62.7 ± 13.3 years, male: 67.4%) at the first 24 hours of admission and 43 normal controls (mean age: 62.1 ± 12.3 years, male: 55.8%) matched for age, sex and other CAD risk factors. RESULTS: Adiponectin levels in patients with AMI (3.36 μg/mL) were significantly lower than that of the control group (5.03 μg/mL) (p < 0.0001). Lower adiponectin were independently associated with higher risk of AMI (odds ratio = 8.97; 95% CIs: 2.3–34.5; p = 0.001). Adiponectin levels negatively correlated with triglyceride (r = -0.46, p = 0.002) and total cholesterol (r = -0.32, p = 0.03) in the case group and with body mass index (BMI) in control subjects. CONCLUSION: The present study showed that adiponectin was associated with AMI in non obese patients but it is not related to sex, age and other CAD risk factors.