The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury

BACKGROUND: Acute kidney injury frequently accompanies sepsis. Endotoxin is known to reduce tissue levels of cAMP and low levels of cAMP have been associated with renal injury. We, therefore, hypothesized that endotoxin induced renal injury by activating phosphodiesterase 3 (PDE3) which metabolizes...

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Detalles Bibliográficos
Autores principales: Choi, Won-Il, Kwon, Kun Young, Seo, Jeong Wook, Beagle, John, Quinn, Deborah A, Hales, Charles A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694814/
https://www.ncbi.nlm.nih.gov/pubmed/19486524
http://dx.doi.org/10.1186/1471-2334-9-80

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