Cargando…

Pulmonary hypertension and chronic cor pulmonale in COPD

Hypoxia and endothelial dysfunction play a central role in the development of pulmonary hypertension. Cor pulmonale is a maladaptive response to pulmonary hypertension. The presence of peripheral edema in cor pulmonale is almost invariably associated with hypercapnia. Correction of abnormalities of...

Descripción completa

Detalles Bibliográficos
Autores principales: Shujaat, Adil, Minkin, Ruth, Eden, Edward
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695205/
https://www.ncbi.nlm.nih.gov/pubmed/18229565
_version_ 1782168168004845568
author Shujaat, Adil
Minkin, Ruth
Eden, Edward
author_facet Shujaat, Adil
Minkin, Ruth
Eden, Edward
author_sort Shujaat, Adil
collection PubMed
description Hypoxia and endothelial dysfunction play a central role in the development of pulmonary hypertension. Cor pulmonale is a maladaptive response to pulmonary hypertension. The presence of peripheral edema in cor pulmonale is almost invariably associated with hypercapnia. Correction of abnormalities of gas exchange and ventilation can ameliorate pulmonary hypertension and improve survival. This review focuses on new information about the pathogenesis and treatment of pulmonary hypertension in COPD including information derived from lung volume reduction surgery, the role of brain natriuretic peptide, exhaled nitric oxide for diagnosis, and the treatment of cor pulmonale with recently available specific pulmonary vasodilators.
format Text
id pubmed-2695205
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-26952052009-06-16 Pulmonary hypertension and chronic cor pulmonale in COPD Shujaat, Adil Minkin, Ruth Eden, Edward Int J Chron Obstruct Pulmon Dis Review Hypoxia and endothelial dysfunction play a central role in the development of pulmonary hypertension. Cor pulmonale is a maladaptive response to pulmonary hypertension. The presence of peripheral edema in cor pulmonale is almost invariably associated with hypercapnia. Correction of abnormalities of gas exchange and ventilation can ameliorate pulmonary hypertension and improve survival. This review focuses on new information about the pathogenesis and treatment of pulmonary hypertension in COPD including information derived from lung volume reduction surgery, the role of brain natriuretic peptide, exhaled nitric oxide for diagnosis, and the treatment of cor pulmonale with recently available specific pulmonary vasodilators. Dove Medical Press 2007-09 2007-09 /pmc/articles/PMC2695205/ /pubmed/18229565 Text en © 2007 Dove Medical Press Limited. All rights reserved
spellingShingle Review
Shujaat, Adil
Minkin, Ruth
Eden, Edward
Pulmonary hypertension and chronic cor pulmonale in COPD
title Pulmonary hypertension and chronic cor pulmonale in COPD
title_full Pulmonary hypertension and chronic cor pulmonale in COPD
title_fullStr Pulmonary hypertension and chronic cor pulmonale in COPD
title_full_unstemmed Pulmonary hypertension and chronic cor pulmonale in COPD
title_short Pulmonary hypertension and chronic cor pulmonale in COPD
title_sort pulmonary hypertension and chronic cor pulmonale in copd
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695205/
https://www.ncbi.nlm.nih.gov/pubmed/18229565
work_keys_str_mv AT shujaatadil pulmonaryhypertensionandchroniccorpulmonaleincopd
AT minkinruth pulmonaryhypertensionandchroniccorpulmonaleincopd
AT edenedward pulmonaryhypertensionandchroniccorpulmonaleincopd