GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?

The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The...

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Detalles Bibliográficos
Autores principales: Marchenkov, Victor V., Semisotnov, Gennady V.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695268/
https://www.ncbi.nlm.nih.gov/pubmed/19564940
http://dx.doi.org/10.3390/ijms10052066
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author Marchenkov, Victor V.
Semisotnov, Gennady V.
author_facet Marchenkov, Victor V.
Semisotnov, Gennady V.
author_sort Marchenkov, Victor V.
collection PubMed
description The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The models of GroEL-assisted protein folding assuming ligand-controlled dissociation of nonnative proteins from the GroEL surface and their folding in the bulk solution are also discussed.
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spelling pubmed-26952682009-06-29 GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity? Marchenkov, Victor V. Semisotnov, Gennady V. Int J Mol Sci Review The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The models of GroEL-assisted protein folding assuming ligand-controlled dissociation of nonnative proteins from the GroEL surface and their folding in the bulk solution are also discussed. Molecular Diversity Preservation International (MDPI) 2009-05-12 /pmc/articles/PMC2695268/ /pubmed/19564940 http://dx.doi.org/10.3390/ijms10052066 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Marchenkov, Victor V.
Semisotnov, Gennady V.
GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?
title GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?
title_full GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?
title_fullStr GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?
title_full_unstemmed GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?
title_short GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?
title_sort groel-assisted protein folding: does it occur within the chaperonin inner cavity?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695268/
https://www.ncbi.nlm.nih.gov/pubmed/19564940
http://dx.doi.org/10.3390/ijms10052066
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AT semisotnovgennadyv groelassistedproteinfoldingdoesitoccurwithinthechaperonininnercavity

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