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A Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles
The goal of present work was to investigate the use of bioerodible polymeric nanoparticles as carriers of retinoic acid (RA), which is known to induce differentiation of several cell lines into neurons. A novel method, named “Colloidal-Coating”, has been developed for the preparation of nanoparticle...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695280/ https://www.ncbi.nlm.nih.gov/pubmed/19564952 http://dx.doi.org/10.3390/ijms10052336 |
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author | Errico, Cesare Gazzarri, Matteo Chiellini, Federica |
author_facet | Errico, Cesare Gazzarri, Matteo Chiellini, Federica |
author_sort | Errico, Cesare |
collection | PubMed |
description | The goal of present work was to investigate the use of bioerodible polymeric nanoparticles as carriers of retinoic acid (RA), which is known to induce differentiation of several cell lines into neurons. A novel method, named “Colloidal-Coating”, has been developed for the preparation of nanoparticles based on a copolymer of maleic anhydride and butyl vinyl ether (VAM41) loaded with RA. Nanoparticles with an average diameter size of 70 nm and good morphology were prepared. The activity of the encapsulated RA was evaluated on SK-N-SH human neuroblastoma cells, which are known to undergo inhibition of proliferation and neuronal differentiation upon treatment with RA. The activity of RA was not affected by the encapsulation and purification processes. |
format | Text |
id | pubmed-2695280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-26952802009-06-29 A Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles Errico, Cesare Gazzarri, Matteo Chiellini, Federica Int J Mol Sci Article The goal of present work was to investigate the use of bioerodible polymeric nanoparticles as carriers of retinoic acid (RA), which is known to induce differentiation of several cell lines into neurons. A novel method, named “Colloidal-Coating”, has been developed for the preparation of nanoparticles based on a copolymer of maleic anhydride and butyl vinyl ether (VAM41) loaded with RA. Nanoparticles with an average diameter size of 70 nm and good morphology were prepared. The activity of the encapsulated RA was evaluated on SK-N-SH human neuroblastoma cells, which are known to undergo inhibition of proliferation and neuronal differentiation upon treatment with RA. The activity of RA was not affected by the encapsulation and purification processes. Molecular Diversity Preservation International (MDPI) 2009-05-19 /pmc/articles/PMC2695280/ /pubmed/19564952 http://dx.doi.org/10.3390/ijms10052336 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Errico, Cesare Gazzarri, Matteo Chiellini, Federica A Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles |
title | A Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles |
title_full | A Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles |
title_fullStr | A Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles |
title_full_unstemmed | A Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles |
title_short | A Novel Method for the Preparation of Retinoic Acid-Loaded Nanoparticles |
title_sort | novel method for the preparation of retinoic acid-loaded nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695280/ https://www.ncbi.nlm.nih.gov/pubmed/19564952 http://dx.doi.org/10.3390/ijms10052336 |
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