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Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy

Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations in the h-current in several animal models. While earlier reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we found an upregulation of I(h...

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Autores principales: Dyhrfjeld-Johnsen, Jonas, Morgan, Robert J., Soltesz, Ivan
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695388/
https://www.ncbi.nlm.nih.gov/pubmed/19753094
http://dx.doi.org/10.3389/neuro.01.005.2009
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author Dyhrfjeld-Johnsen, Jonas
Morgan, Robert J.
Soltesz, Ivan
author_facet Dyhrfjeld-Johnsen, Jonas
Morgan, Robert J.
Soltesz, Ivan
author_sort Dyhrfjeld-Johnsen, Jonas
collection PubMed
description Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations in the h-current in several animal models. While earlier reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we found an upregulation of I(h) in hyperexcitable CA1 pyramidal neuron dendrites following experimental febrile seizures. In addition, in several CA1 pyramidal neuron computational models of different complexity, h-current upregulation has been shown to lead to pro-excitable effects. This focused review examines the complex impact of altered h-current on neuronal resting membrane potential (RMP) and input resistance (R(in)), as well as reported interactions with other ionic conductances.
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spelling pubmed-26953882009-06-16 Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy Dyhrfjeld-Johnsen, Jonas Morgan, Robert J. Soltesz, Ivan Front Neurosci Neuroscience Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations in the h-current in several animal models. While earlier reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we found an upregulation of I(h) in hyperexcitable CA1 pyramidal neuron dendrites following experimental febrile seizures. In addition, in several CA1 pyramidal neuron computational models of different complexity, h-current upregulation has been shown to lead to pro-excitable effects. This focused review examines the complex impact of altered h-current on neuronal resting membrane potential (RMP) and input resistance (R(in)), as well as reported interactions with other ionic conductances. Frontiers Research Foundation 2009-05-01 /pmc/articles/PMC2695388/ /pubmed/19753094 http://dx.doi.org/10.3389/neuro.01.005.2009 Text en Copyright © 2009 Dyhrfjeld-Johnsen, Morgan and Soltesz. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Dyhrfjeld-Johnsen, Jonas
Morgan, Robert J.
Soltesz, Ivan
Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy
title Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy
title_full Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy
title_fullStr Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy
title_full_unstemmed Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy
title_short Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy
title_sort double trouble? potential for hyperexcitability following both channelopathic up- and downregulation of i(h) in epilepsy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695388/
https://www.ncbi.nlm.nih.gov/pubmed/19753094
http://dx.doi.org/10.3389/neuro.01.005.2009
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