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Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy
Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations in the h-current in several animal models. While earlier reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we found an upregulation of I(h...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695388/ https://www.ncbi.nlm.nih.gov/pubmed/19753094 http://dx.doi.org/10.3389/neuro.01.005.2009 |
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author | Dyhrfjeld-Johnsen, Jonas Morgan, Robert J. Soltesz, Ivan |
author_facet | Dyhrfjeld-Johnsen, Jonas Morgan, Robert J. Soltesz, Ivan |
author_sort | Dyhrfjeld-Johnsen, Jonas |
collection | PubMed |
description | Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations in the h-current in several animal models. While earlier reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we found an upregulation of I(h) in hyperexcitable CA1 pyramidal neuron dendrites following experimental febrile seizures. In addition, in several CA1 pyramidal neuron computational models of different complexity, h-current upregulation has been shown to lead to pro-excitable effects. This focused review examines the complex impact of altered h-current on neuronal resting membrane potential (RMP) and input resistance (R(in)), as well as reported interactions with other ionic conductances. |
format | Text |
id | pubmed-2695388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-26953882009-06-16 Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy Dyhrfjeld-Johnsen, Jonas Morgan, Robert J. Soltesz, Ivan Front Neurosci Neuroscience Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations in the h-current in several animal models. While earlier reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we found an upregulation of I(h) in hyperexcitable CA1 pyramidal neuron dendrites following experimental febrile seizures. In addition, in several CA1 pyramidal neuron computational models of different complexity, h-current upregulation has been shown to lead to pro-excitable effects. This focused review examines the complex impact of altered h-current on neuronal resting membrane potential (RMP) and input resistance (R(in)), as well as reported interactions with other ionic conductances. Frontiers Research Foundation 2009-05-01 /pmc/articles/PMC2695388/ /pubmed/19753094 http://dx.doi.org/10.3389/neuro.01.005.2009 Text en Copyright © 2009 Dyhrfjeld-Johnsen, Morgan and Soltesz. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Dyhrfjeld-Johnsen, Jonas Morgan, Robert J. Soltesz, Ivan Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy |
title | Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy |
title_full | Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy |
title_fullStr | Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy |
title_full_unstemmed | Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy |
title_short | Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy |
title_sort | double trouble? potential for hyperexcitability following both channelopathic up- and downregulation of i(h) in epilepsy |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695388/ https://www.ncbi.nlm.nih.gov/pubmed/19753094 http://dx.doi.org/10.3389/neuro.01.005.2009 |
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